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Review
. 2022 Aug 18:9:972379.
doi: 10.3389/fnut.2022.972379. eCollection 2022.

Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation

Urooj Fatima  1 , Sonam Roy  1 , Shahnawaz Ahmad  2 , Sabeeha Ali  1 , Wafaa M Elkady  3 , Ilyas Khan  4 , Rana M Alsaffar  5 , Mohd Adnan  6 , Asimul Islam  1 , Md Imtaiyaz Hassan  1
Affiliations
Review

Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation

Urooj Fatima et al. Front Nutr. .

Abstract

Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in combination with other herbs, as a memory and learning enhancer, sedative, and anti-epileptic. This review aimed to highlight the health benefits of B. monnieri extracts (BME), focusing on anti-cancer and neurodegenerative diseases. We examined the clinical studies on phytochemistry and pharmacological application of BME. We further highlighted the mechanism of action of these extracts in varying types of cancer and their therapeutic implications. In addition, we investigated the underlying molecular mechanism in therapeutic interventions, toxicities, safety concerns and synergistic potential in cognition and neuroprotection. Overall, this review provides deeper insights into the therapeutic implications of Brahmi as a lead formulation for treating neurological disorders and exerting cognitive-enhancing effects.

Keywords: Bacopa monnieri; anti-cancer agents; neurodegenerative diseases; pharmacological potential; tau aggregates.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
An overview of the pharmacological effects of major bioactive constituents of Bacopa monnieri.
Figure 2
Figure 2
Representative structures of major phytoconstituents present in extracts of Bacopa monnieri. Structures were downloaded from PubChem (https://pubchem.ncbi.nlm.nih.gov) with their corresponding PubChem CIDs, Bacoside A (92043183), Bacoside B (121596009), Bacogenin A (101600046), Bacopaside I (21599442), Bacopasaponin C (21599443), Cucurbitacin B (5281316), Bacosine (71312547), and Stigmasterol (5280794).
Figure 3
Figure 3
The action mechanism of Bacopa monnieri against neurodegenerative diseases.
Figure 4
Figure 4
The Global concept of standardization, quality evaluation and pharmacological validation for the development of herbal medicine.
See this image and copyright information in PMC

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References

    1. Jain PK, Das D, Jain P, Jain P, Jain PK. Pharmacognostic and pharmacological aspect of Bacopa monnieri - a review. Innovare J Ayurvedic Sci. (2016) 4, 796-11.
    1. Chaudhari KS, Tiwari NR, Tiwari RR, Sharma RS. Neurocognitive effect of nootropic drug Brahmi (Bacopa monnieri) in Alzheimer's disease. Ann Neurosci. (2017) 24:111–22. 10.1159/000475900 - DOI - PMC - PubMed
    1. Bhattacharya S, Bhattacharya A, Kumar A, Ghosal S. Antioxidant activity ofBacopa monniera in rat frontal cortex, striatum and hippocampus. Phytother Res. (2000) 14:174–9. 10.1002/(SICI)1099-1573(200005)14:3andlt;174::AID-PTR624andgt;3.0.CO;2-O - DOI - PubMed
    1. Kapoor R, Srivastava S, Kakkar P. Bacopa monnieri modulates antioxidant responses in brain and kidney of diabetic rats. Environ Toxicol Pharmacol. (2009) 27:62–9. 10.1016/j.etap.2008.08.007 - DOI - PubMed
    1. Anbarasi K, Vani G, Balakrishna K, Devi CS. Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats. Life Sci. (2006) 78:1378–84. 10.1016/j.lfs.2005.07.030 - DOI - PubMed

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