Surface-Active Compounds Produced by Microorganisms: Promising Molecules for the Development of Antimicrobial, Anti-Inflammatory, and Healing Agents

doi:10.3390/antibiotics11081106

Review

. 2022 Aug 16;11(8):1106.

doi: 10.3390/antibiotics11081106.

Surface-Active Compounds Produced by Microorganisms: Promising Molecules for the Development of Antimicrobial, Anti-Inflammatory, and Healing Agents

Jéssica Araujo^{1

2}, Joveliane Monteiro^{1

2}, Douglas Silva², Amanda Alencar², Kariny Silva², Lara Coelho², Wallace Pacheco², Darlan Silva³, Maria Silva³, Luís Silva^{1

4}, Andrea Monteiro^{1

2}

Affiliations

¹ Rede de Biodiversidade e Biotecnologia da Amazônia Legal, BIONORTE, São Luís 65055-310, MA, Brazil.
² Laboratório de Microbiologia Aplicada, Universidade CEUMA, São Luís 65075-120, MA, Brazil.
³ Laboratório de Ciências do Ambiente, Universidade CEUMA, São Luís 65075-120, MA, Brazil.
⁴ Laboratório de Patogenicidade Microbiana, Universidade CEUMA, São Luís 65075-120, MA, Brazil.

PMID: 36009975
PMCID: PMC9404966
DOI: 10.3390/antibiotics11081106

Review

Surface-Active Compounds Produced by Microorganisms: Promising Molecules for the Development of Antimicrobial, Anti-Inflammatory, and Healing Agents

Jéssica Araujo et al. Antibiotics (Basel). 2022.

. 2022 Aug 16;11(8):1106.

doi: 10.3390/antibiotics11081106.

Authors

Affiliations

¹ Rede de Biodiversidade e Biotecnologia da Amazônia Legal, BIONORTE, São Luís 65055-310, MA, Brazil.
² Laboratório de Microbiologia Aplicada, Universidade CEUMA, São Luís 65075-120, MA, Brazil.
³ Laboratório de Ciências do Ambiente, Universidade CEUMA, São Luís 65075-120, MA, Brazil.
⁴ Laboratório de Patogenicidade Microbiana, Universidade CEUMA, São Luís 65075-120, MA, Brazil.

PMID: 36009975
PMCID: PMC9404966
DOI: 10.3390/antibiotics11081106

Abstract

Surface-active compounds (SACs), biomolecules produced by bacteria, yeasts, and filamentous fungi, have interesting properties, such as the ability to interact with surfaces as well as hydrophobic or hydrophilic interfaces. Because of their advantages over other compounds, such as biodegradability, low toxicity, antimicrobial, and healing properties, SACs are attractive targets for research in various applications in medicine. As a result, a growing number of properties related to SAC production have been the subject of scientific research during the past decade, searching for potential future applications in biomedical, pharmaceutical, and therapeutic fields. This review aims to provide a comprehensive understanding of the potential of biosurfactants and emulsifiers as antimicrobials, modulators of virulence factors, anticancer agents, and wound healing agents in the field of biotechnology and biomedicine, to meet the increasing demand for safer medical and pharmacological therapies.

Keywords: bioemulsifier; biological properties; biosurfactants; biotechnology; surface-active compounds.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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1. Durval I.J.B., Mendonça A.H.R., Rocha I.V., Luna J.M., Rufino R.D., Converti A., Sarubbo L.A. Production, Characterization, Evaluation and Toxicity Assessment of a Bacillus cereus UCP 1615 Biosurfactant for Marine Oil Spills Bioremediation. Mar. Pollut. Bull. 2020;157:111357. doi: 10.1016/j.marpolbul.2020.111357. - DOI - PubMed
1. Ceresa C., Tessarolo F., Maniglio D., Tambone E., Carmagnola I., Fedeli E., Caola I., Nollo G., Chiono V., Allegrone G., et al. Medical-Grade Silicone Coated with Rhamnolipid R89 Is Effective against Staphylococcus spp. Biofilms. Molecules. 2019;24:3843. doi: 10.3390/molecules24213843. - DOI - PMC - PubMed

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This study was financed in part by Fundação de Amparo à Pesquisa e o Desenvolvimento Científico e Tecnológico do Maranhão (FAPEMA, BD-01413/19); and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ, 434149/2018-7).

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[1] Franzetti A., Tamburini E., Banat I.M. Applications of Biological Surface-Active Compounds in Remediation Technologies. Adv. Exp. Med. Biol. 2010;672:121–134. doi: 10.1007/978-1-4419-5979-9_9. - DOI - PubMed

[2] Franzetti A., Tamburini E., Banat I.M. Applications of Biological Surface-Active Compounds in Remediation Technologies. Adv. Exp. Med. Biol. 2010;672:121–134. doi: 10.1007/978-1-4419-5979-9_9. - DOI - PubMed

[3] Phulpoto I.A., Yu Z., Hu B., Wang Y., Ndayisenga F., Li J., Liang H., Qazi M.A. Production and Characterization of Surfactin-like Biosurfactant Produced by Novel Strain Bacillus nealsonii S2MT and It’s Potential for Oil Contaminated Soil Remediation. Microb. Cell Fact. 2020;19:145. doi: 10.1186/s12934-020-01402-4. - DOI - PMC - PubMed

[4] Phulpoto I.A., Yu Z., Hu B., Wang Y., Ndayisenga F., Li J., Liang H., Qazi M.A. Production and Characterization of Surfactin-like Biosurfactant Produced by Novel Strain Bacillus nealsonii S2MT and It’s Potential for Oil Contaminated Soil Remediation. Microb. Cell Fact. 2020;19:145. doi: 10.1186/s12934-020-01402-4. - DOI - PMC - PubMed

[5] Uzoigwe C., Burgess J.G., Ennis C.J., Rahman P.K.S.M. Bioemulsifiers Are Not Biosurfactants and Require Different Screening Approaches. Front. Microbiol. 2015;6:245. doi: 10.3389/fmicb.2015.00245. - DOI - PMC - PubMed

[6] Uzoigwe C., Burgess J.G., Ennis C.J., Rahman P.K.S.M. Bioemulsifiers Are Not Biosurfactants and Require Different Screening Approaches. Front. Microbiol. 2015;6:245. doi: 10.3389/fmicb.2015.00245. - DOI - PMC - PubMed

[7] Durval I.J.B., Mendonça A.H.R., Rocha I.V., Luna J.M., Rufino R.D., Converti A., Sarubbo L.A. Production, Characterization, Evaluation and Toxicity Assessment of a Bacillus cereus UCP 1615 Biosurfactant for Marine Oil Spills Bioremediation. Mar. Pollut. Bull. 2020;157:111357. doi: 10.1016/j.marpolbul.2020.111357. - DOI - PubMed

[8] Durval I.J.B., Mendonça A.H.R., Rocha I.V., Luna J.M., Rufino R.D., Converti A., Sarubbo L.A. Production, Characterization, Evaluation and Toxicity Assessment of a Bacillus cereus UCP 1615 Biosurfactant for Marine Oil Spills Bioremediation. Mar. Pollut. Bull. 2020;157:111357. doi: 10.1016/j.marpolbul.2020.111357. - DOI - PubMed

[9] Ceresa C., Tessarolo F., Maniglio D., Tambone E., Carmagnola I., Fedeli E., Caola I., Nollo G., Chiono V., Allegrone G., et al. Medical-Grade Silicone Coated with Rhamnolipid R89 Is Effective against Staphylococcus spp. Biofilms. Molecules. 2019;24:3843. doi: 10.3390/molecules24213843. - DOI - PMC - PubMed

[10] Ceresa C., Tessarolo F., Maniglio D., Tambone E., Carmagnola I., Fedeli E., Caola I., Nollo G., Chiono V., Allegrone G., et al. Medical-Grade Silicone Coated with Rhamnolipid R89 Is Effective against Staphylococcus spp. Biofilms. Molecules. 2019;24:3843. doi: 10.3390/molecules24213843. - DOI - PMC - PubMed

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Surface-Active Compounds Produced by Microorganisms: Promising Molecules for the Development of Antimicrobial, Anti-Inflammatory, and Healing Agents

Affiliations

Surface-Active Compounds Produced by Microorganisms: Promising Molecules for the Development of Antimicrobial, Anti-Inflammatory, and Healing Agents

Authors

Affiliations

Abstract

Conflict of interest statement

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Cited by

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources

Research Materials

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