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. 2022 Aug;13(4):389-397.
doi: 10.1007/s12687-022-00601-3. Epub 2022 Jul 14.

Variation among DNA banking consent forms: points for clinicians to bank on

Samuel J Huang  1 , Laura M Amendola  2 , Darci L Sternen  3
Affiliations

Variation among DNA banking consent forms: points for clinicians to bank on

Samuel J Huang et al. J Community Genet. 2022 Aug.

Abstract

Deoxyribonucleic acid (DNA) banking is an important laboratory service that preserves the option of future genetic testing. DNA bank consent forms are a critical tool to facilitate thorough and valid informed consent. The objectives of this study were to assess the level of consistency of current clinical DNA banking consent forms with the American Society of Human Genetics (ASHG) and the American College of Medical Genetics and Genomics (ACMG) guidance and to explore variation among the forms. The content analysis matrix included key points identified from the ASHG and ACMG documents (including benefits/risks, sample storage, access, disposition, and communication) and additional points beyond the ASHG and ACMG documents identified from the consent forms themselves during the analysis process. Forms were assessed for language addressing each point. Five consent forms were identified and analyzed for twelve key points and eight additional points. The average consistency for key points was 10.8/12 (range 8/12 to 12/12). The range for additional points was 1/8 to 5/8. There was variation across forms in the details provided related to key and additional points. Gaps in clinical DNA banking consent forms are barriers to achieving informed consent. Clinicians can consider the consent key and additional points discussed here to supplement and enrich their clinical DNA banking informed consent discussions, promote stewardship, and maximize downstream utility of banked DNA. The identification of multiple additional points beyond the ASHG and ACMG documents' key points indicates a need for this guidance to be updated.

Keywords: Biobanking; DNA banking; Informed consent; Stewardship.

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Conflict of interest statement

Darci L. Sternen is employed by Seattle Children’s Hospital Laboratory, which offered a DNA bank service until 2020. Laura M. Amendola is an employee of Illumina, Inc. Samuel J. Huang declares no potential conflict of interest.

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