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Review
. 2021 Oct;35(10):5668-5679.
doi: 10.1002/ptr.7203. Epub 2021 Jul 12.

Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders

Samarpita Banerjee  1 , Uttpal Anand  2 , Suchhanda Ghosh  1 , Durga Ray  3 , Puja Ray  4 , Samapika Nandy  4 , Ganpat Dewaji Deshmukh  5 , Vijay Tripathi  6 , Abhijit Dey  4
Affiliations
Review

Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders

Samarpita Banerjee et al. Phytother Res. 2021 Oct.

Abstract

From ancient history, complementary and alternative medicines have played a significant role as holistic therapeutic treatments of various human diseases including cancer, diabetes, neurological diseases, and skin problems. One Indian medicinal plant (herb), Bacopa monnieri has been used in many parts of the world as such medicine, particularly for the treatment of various neurological disorders. It is well known as a potent "tonic for the human brain," which serves as a memory enhancer. Multiple studies proved that this herb contains a plethora of potential bioactive, phytochemical compounds with synergistic properties. The main purpose of the present review is to shed light on the use of Bacopa monnieri and its active principles (bacosides) in the management of neurological disorders. Furthermore, the signaling pathways modulated by bacosides have been critically discussed in this review. Moreover, we have critically summarized the present knowledge of this perennial creeping herb based upon the literature mining from different scientific engines.

Keywords: Bacopa monnieri; bioactive; complementary and alternative medicines; neurological disorders; nootropic; phytochemical.

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References

REFERENCES

    1. Agarwal, S., Chaudhary, B., & Bist, R. (2017). Protective propensity of bacoside A and bromelain on renal cholinesterases, γ-aminobutyric acid and serotonin level of Mus musculus intoxicated with dichlorvos. Chemico-biological interactions, 261, 139-144.
    1. Anabarasi, K., Kathirvel, G., Vani, G., Jayaraman, G., & Devi, C. S. S. (2006). Cigarette smoking induces heat shock protein 70 kDa expression and apoptosis in rat brain: Modulation by bacoside A. Neuroscience, 138(4), 1127-1135.
    1. Anabarasi, K., Vani, G., Balakrishna, K., & Devi, C. S. S. (2005a). Creatine kinase isoenzyme patterns upon chronic exposure to cigarette smoke: Protective effect of Bacoside A. Vascular Pharmacology, 42(2), 57-61.
    1. Anabarasi, K., Vani, G., Balakrishna, K., & Devi, C. S. S. (2005b). Effect of bacoside A on membrane-bound ATPases in the brains of rats exposed to cigarette smoke. Journal of Biochemical and Molecular Toxicology, 19(1), 59-65.
    1. Anabarasi, K., Vani, G., Balakrishna, K., & Devi, C. S. S. (2006). Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats. Life Sciences, 78(12), 1378-1384.

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