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Review

Tofacitinib

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
Free Books & Documents
Review

Tofacitinib

No authors listed.
Free Books & Documents

Excerpt

Data from 2 mothers indicate that the amount in milk is relatively low and no adverse effects were seen in infants who were exclusively breastfed during maternal tofacitinib use. Until more data become available, tofacitinib should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. Expert opinion considers breastfeeding to be unadvisable during tofacitinib use.[1] The manufacturer and an expert panel recommend that breastfeeding be discontinued during tofacitinib therapy and for 18 hours after the last dose of the immediate-release product or 36 hours after the last dose of the sustained-release product.[2]

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References

    1. Selinger C, Laube R, Limdi JK, et al. Appropriateness of small molecule agents for patients with IBD of childbearing age - a RAND/UCLA appropriateness panel. Therap Adv Gastroenterol 2024;17:17562848241299737. - PMC - PubMed
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    1. Mitrova K, Julsgaard M, Augustijns P, et al. Tofacitinib in pregnancy: Assessing pregnancy and infant outcomes, cord blood and breast milk concentrations. Clin Gastroenterol Hepatol 2025;23:163-65.e3. - PubMed
    1. Ernest-Suarez K, Murguía-Favela LE, Novak KL, et al. Normal infant immunologic assessment and uneventful live rotavirus vaccination despite continuous tofacitinib exposure in utero and during breastfeeding. Crohns Colitis 360 2024;6:otae006. - PMC - PubMed

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