Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules

doi:10.1007/978-1-4939-7240-1_31

Review

. 2017:1657:419-430.

doi: 10.1007/978-1-4939-7240-1_31.

Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules

Clement Opoku-Temeng^{1

2

3}, Herman O Sintim^{4

5

6}

Affiliations

¹ Purdue Institute for Drug Discovery, Purdue University, 500 Oval Drive, West Lafayette, IN, 47907, USA.
² Biochemistry Graduate Program, University of Maryland, College Park, MD, 20742, USA.
³ Department of Chemistry, Center for Drug Discovery, Purdue University, West Lafayette, IN, 47907, USA.
⁴ Purdue Institute for Drug Discovery, Purdue University, 500 Oval Drive, West Lafayette, IN, 47907, USA. hsintim@purdue.edu.
⁵ Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA. hsintim@purdue.edu.
⁶ Purdue Institute of Inflammation, Immunology and Infectious Disease, West Lafayette, IN, 47907, USA. hsintim@purdue.edu.

PMID: 28889311
DOI: 10.1007/978-1-4939-7240-1_31

Review

Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules

Clement Opoku-Temeng et al. Methods Mol Biol. 2017.

. 2017:1657:419-430.

doi: 10.1007/978-1-4939-7240-1_31.

Authors

Clement Opoku-Temeng^{1

2

3}, Herman O Sintim^{4

5

6}

Affiliations

¹ Purdue Institute for Drug Discovery, Purdue University, 500 Oval Drive, West Lafayette, IN, 47907, USA.
² Biochemistry Graduate Program, University of Maryland, College Park, MD, 20742, USA.
³ Department of Chemistry, Center for Drug Discovery, Purdue University, West Lafayette, IN, 47907, USA.
⁴ Purdue Institute for Drug Discovery, Purdue University, 500 Oval Drive, West Lafayette, IN, 47907, USA. hsintim@purdue.edu.
⁵ Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA. hsintim@purdue.edu.
⁶ Purdue Institute of Inflammation, Immunology and Infectious Disease, West Lafayette, IN, 47907, USA. hsintim@purdue.edu.

PMID: 28889311
DOI: 10.1007/978-1-4939-7240-1_31

Abstract

Bacteria possess several signaling molecules that regulate distinct phenotypes. Cyclic di-GMP (c-di-GMP) has emerged as a ubiquitous second messenger that regulates bacterial virulence, cell cycle, motility, and biofilm formation. The link between c-di-GMP signaling and biofilm formation affords novel strategies for treatment of biofilm-associated infections, which is a major public health problem. The complex c-di-GMP signaling pathway creates a hurdle in the development of small molecule modulators. Nonetheless, some progress has been made in this regard and inhibitors of c-di-GMP metabolizing enzymes that affect biofilm formation and motility have been documented. Herein we discuss the components of c-di-GMP signaling, their correlation with biofilm formation as well as motility and reported small molecule inhibitors of c-di-GMP signaling.

Keywords: Diguanylate cyclase; Inhibitor; Phosphodiesterase; PilZ; STING; c-di-GMP.

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Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules

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Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules

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