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Review
. 2016 Nov 15;106(Pt B):242-255.
doi: 10.1016/j.addr.2016.04.014. Epub 2016 Apr 23.

Mechanisms of transport of polymeric and lipidic nanoparticles across the intestinal barrier

Ana Beloqui  1 , Anne des Rieux  2 , Véronique Préat  3
Affiliations
Review

Mechanisms of transport of polymeric and lipidic nanoparticles across the intestinal barrier

Ana Beloqui et al. Adv Drug Deliv Rev. .

Abstract

Unraveling the mechanisms of nanoparticle transport across the intestinal barrier is essential for designing more efficient nanoparticles for oral administration. The physicochemical parameters of the nanoparticles (e.g., size, surface charge, chemical composition) dictate nanoparticle fate across the intestinal barrier. This review aims to address the most important findings regarding polymeric and lipidic nanoparticle transport across the intestinal barrier, including the evaluation of critical physicochemical parameters of nanoparticles that affect nanocarrier interactions with the intestinal barrier.

Keywords: Caco-2; Endocytosis; HT29-MTX; In vitro models; M cells; Nanoparticles; Transport mechanisms.

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