Chikungunya vaccines in development

doi:10.1080/21645515.2015.1101197

Review

. 2016 Mar 3;12(3):716-31.

doi: 10.1080/21645515.2015.1101197.

Chikungunya vaccines in development

Michael Schwameis¹, Nina Buchtele¹, Patricia Pia Wadowski¹, Christian Schoergenhofer², Bernd Jilma¹

Affiliations

¹ a Departments of Clinical Pharmacology and Internal Medicine I , Medical University of Vienna , Vienna , Austria.
² b Internal Medicine I Medical University of Vienna , Vienna , Austria.

PMID: 26554522
PMCID: PMC4964651
DOI: 10.1080/21645515.2015.1101197

Review

Chikungunya vaccines in development

Michael Schwameis et al. Hum Vaccin Immunother. 2016.

. 2016 Mar 3;12(3):716-31.

doi: 10.1080/21645515.2015.1101197.

Authors

Michael Schwameis¹, Nina Buchtele¹, Patricia Pia Wadowski¹, Christian Schoergenhofer², Bernd Jilma¹

Affiliations

¹ a Departments of Clinical Pharmacology and Internal Medicine I , Medical University of Vienna , Vienna , Austria.
² b Internal Medicine I Medical University of Vienna , Vienna , Austria.

PMID: 26554522
PMCID: PMC4964651
DOI: 10.1080/21645515.2015.1101197

Abstract

Chikungunya virus has become a global health threat, spreading to the industrial world of Europe and the Americas; no treatment or prophylactic vaccine is available. Since the late 1960s much effort has been put into the development of a vaccine, and several heterogeneous strategies have already been explored. Only two candidates have recently qualified to enter clinical phase II trials, a chikungunya virus-like particle-based vaccine and a recombinant live attenuated measles virus-vectored vaccine. This review focuses on the current status of vaccine development against chikungunya virus in humans and discusses the diversity of immunization strategies, results of recent human trials and promising vaccine candidates.

Keywords: Chikungunya; clinical trials; live virus vaccine; measles virus; review; virus-like particles.

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References

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[1] Weaver SC, Lecuit M. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med 2015; 372:1231-9; PMID:25806915; http://dx.doi.org/10.1056/NEJMra1406035 - DOI - PubMed

[2] Weaver SC, Lecuit M. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med 2015; 372:1231-9; PMID:25806915; http://dx.doi.org/10.1056/NEJMra1406035 - DOI - PubMed

[3] Robinson MC. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features. Trans R Soc Trop Med Hyg 1955; 49:28-32; PMID:14373834; http://dx.doi.org/10.1016/0035-9203(55)90080-8 - DOI - PubMed

[4] Robinson MC. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features. Trans R Soc Trop Med Hyg 1955; 49:28-32; PMID:14373834; http://dx.doi.org/10.1016/0035-9203(55)90080-8 - DOI - PubMed

[5] Rezza G. Dengue and chikungunya: long-distance spread and outbreaks in naive areas. Pathog Glob Health 2014; 108:349-55; PMID:25491436; http://dx.doi.org/10.1179/2047773214Y.0000000163 - DOI - PMC - PubMed

[6] Rezza G. Dengue and chikungunya: long-distance spread and outbreaks in naive areas. Pathog Glob Health 2014; 108:349-55; PMID:25491436; http://dx.doi.org/10.1179/2047773214Y.0000000163 - DOI - PMC - PubMed

[7] WHO Chikungunya Fact sheet N°327. 2015; http://www.who.int/mediacentre/factsheets/fs327/en/ (accessed June 18th, 2015).

[8] WHO Chikungunya Fact sheet N°327. 2015; http://www.who.int/mediacentre/factsheets/fs327/en/ (accessed June 18th, 2015).

[9] Ross RW. The Newala epidemic. III. The virus: isolation, pathogenic properties and relationship to the epidemic. J Hyg 1956; 54:177-91; PMID:13346078; http://dx.doi.org/10.1017/S0022172400044442 - DOI - PMC - PubMed

[10] Ross RW. The Newala epidemic. III. The virus: isolation, pathogenic properties and relationship to the epidemic. J Hyg 1956; 54:177-91; PMID:13346078; http://dx.doi.org/10.1017/S0022172400044442 - DOI - PMC - PubMed

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Chikungunya vaccines in development

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