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. 2014;10(12):3517-21.
doi: 10.4161/21645515.2014.979625.

Use of surveillance data to identify target populations for Staphylococcus aureus vaccines and prevent surgical site infections: a pilot study

Marie-Paule Gustin  1 , Marine Giard, Thomas Bénet, Philippe Vanhems
Affiliations

Use of surveillance data to identify target populations for Staphylococcus aureus vaccines and prevent surgical site infections: a pilot study

Marie-Paule Gustin et al. Hum Vaccin Immunother. 2014.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Hum Vaccin Immunother. 2015;11(10):2511. doi: 10.1080/21645515.2015.1082392. Hum Vaccin Immunother. 2015. PMID: 26376018 Free PMC article. No abstract available.

Abstract

The development of anti-staphylococcal vaccines is nowadays a priority to prevent surgical site infections (SSI). The objective of the present study was to identify a potential target population by assessing surveillance data on surgery patients for possible anti-staphylococcal vaccine administration. Individuals at high risk of SSI by Staphylococcus aureus (SA) were targeted by the French SSI Surveillance Network in south-eastern France between 2008 and 2011. Among 238,470 patients, those undergoing primary total hip replacement appeared to be an interesting and healthy enough population for anti-staphylococcal vaccine testing. These male patients, subjected to multiple procedures and with American Society of Anesthesiologists score>2, had a probability of SA SSI about 21 times higher than females with no severe systemic disease and no multiple procedures. Our study indicates that surveillance data on SSI might be an interesting epidemiological source for planning vaccine trials to prevent nosocomial infections.

Keywords: ASA, American Society of Anesthesiologists; CI, confidence interval; OR, Odds ratio; SA, Staphylococcus aureus; SSI, surgical site infection; Staplylococcus aureus; orthopedic surgery; surgical site infection; surveillance; target population; vaccination.

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Figures

Figure 1.
Figure 1.
Flow chart of hospitalizations in the French SSI Surveillance Network during the period 2008–2011. Abbreviation: SA SSI: surgical site infections by Staphylococcus aureus. The right side of the figure reports successively excluded observations, and the left side, the remaining numbers of SA SSI.
Figure 2.
Figure 2.
Predicted Staphylococcus aureus surgical site infection (SA SSI) rate according to number of interventions per operative procedure category. Each plot represents an operating procedure. SA SSI rates are expressed in terms of SA SSI per 1,000 patients. Triangles represent procedures with the highest SSI rate (>0.5 per 1,000 patients), orthopedic surgeries are in gray [NTHR: non-total hip replacement; HRR: hip replacement revision; THR: total hip replacement; BRES: breast surgery; CSEC: cesarean section; LAM: laminectomy; DISH: lumbar disc hernia surgery; CABG: coronary artery bypass graft; ABLA: ablation of ostheosynthesis materials].
Figure 3.
Figure 3.
Evolution of SA SSI rate as a function of risk factor level according to a 4-point score in patients undergoing primary hip replacement.
See this image and copyright information in PMC

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