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Review
. 2015 Dec;172(23):5523-30.
doi: 10.1111/bph.13105. Epub 2015 Mar 27.

Class A1 scavenger receptors in cardiovascular diseases

Jingjing Ben  1 , Xudong Zhu  1 , Hanwen Zhang  1 , Qi Chen  1
Affiliations
Review

Class A1 scavenger receptors in cardiovascular diseases

Jingjing Ben et al. Br J Pharmacol. 2015 Dec.

Abstract

Class A1 scavenger receptors (SR-A1) are membrane glycoproteins that can form homotrimers. This receptor was originally defined by its ability to mediate the accumulation of lipids in macrophages. Subsequent studies reveal that SR-A1 plays critical roles in innate immunity, cell apoptosis and proliferation. This review highlights recent advances in understanding the structure, receptor pathway and regulation of SR-A1. Although its role in atherosclerosis is disputable, recent discoveries suggest that SR-A1 function in anti-inflammatory responses by promoting an M2 macrophage phenotype in cardiovascular diseases. Therefore, SR-A1 may be a potential target for therapeutic intervention of cardiovascular diseases.

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Figures

Figure 1
Figure 1
Members of class A scavenger receptor family. The members of class A scavenger receptor family have a similar structure that is composed of a cytoplasmic tail, a transmembrane domain, a spacer region, a helical coiled coil domain, a collagenous domain and a C‐terminal cysteine‐rich domain.
Figure 2
Figure 2
SR‐A1‐regulated macrophage activities in cardiovascular diseases.
See this image and copyright information in PMC

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