Biological activities and possible dental application of three major groups of polyphenols
- PMID: 25263279
- DOI: 10.1254/jphs.14r04cr
Biological activities and possible dental application of three major groups of polyphenols
Abstract
The present article reviewed the biological activities and possible dental application of three major polyphenols, i.e., lignin-carbohydrate complexes, tannins, and flavonoids, citing mostly our in vitro studies together with those from other groups. All these polyphenols showed much lower tumor-selective cytotoxicity against oral squamous cell carcinoma cells vs. normal oral cells (gingival fibroblast, pulp cell, periodontal ligament fibroblast), in comparison to popular chemotherapeutic antitumor drugs. Several compounds showing higher tumor-selectivity did not induce internucleosomal DNA fragmentation, a biochemical hallmark of apoptosis, in oral carcinoma cell lines. Lignin-carbohydrate complex protected the cells from the cytopathic effects of HIV infection and UV irradiation more efficiently than other polyphenols. Limited digestion of lignin-carbohydrate complex suggests that the lignin moiety is involved in the prominent anti-HIV activity, whereas the carbohydrate moiety may function in immunopotentiating activity through a cell surface receptor. Alkaline extract of plant leaf, which contains higher amounts of lignin-carbohydrate complex, showed potent anti-inflammatory action against IL-1β-stimulated human gingival fibroblasts. Local application of lignin-carbohydrate complex through oral mucosa is recommended, considering its poor intestinal absorption.
Similar articles
-
Cytotoxicity of dental compounds towards human oral squamous cell carcinoma and normal oral cells.In Vivo. 2013 Jan-Feb;27(1):85-95. In Vivo. 2013. PMID: 23239856
-
Tumor-specific cytotoxicity and type of cell death induced by peplomycin in oral squamous cell carcinoma cell lines.Anticancer Res. 2008 Jul-Aug;28(4B):2197-204. Anticancer Res. 2008. PMID: 18751395
-
Tumor-specific cytotoxicity and apoptosis-inducing activity of berberines.Anticancer Res. 2005 Nov-Dec;25(6B):4053-9. Anticancer Res. 2005. PMID: 16309199
-
Selective toxicity and type of cell death induced by various natural and synthetic compounds in oral squamous cell carcinoma.In Vivo. 2007 Mar-Apr;21(2):311-20. In Vivo. 2007. PMID: 17436582 Review.
-
Recent Progress of Basic Studies of Natural Products and Their Dental Application.Medicines (Basel). 2018 Dec 25;6(1):4. doi: 10.3390/medicines6010004. Medicines (Basel). 2018. PMID: 30585249 Free PMC article. Review.
Cited by
-
Dental Application of Natural Products.Medicines (Basel). 2018 Feb 14;5(1):21. doi: 10.3390/medicines5010021. Medicines (Basel). 2018. PMID: 29443874 Free PMC article. Review.
-
Multi-Omics Analysis of Anti-Inflammatory Action of Alkaline Extract of the Leaves of Sasa sp.J Clin Med. 2021 May 13;10(10):2100. doi: 10.3390/jcm10102100. J Clin Med. 2021. PMID: 34068182 Free PMC article.
-
The Role of Equilibrium between Free Radicals and Antioxidants in Depression and Bipolar Disorder.Medicines (Basel). 2022 Nov 14;9(11):57. doi: 10.3390/medicines9110057. Medicines (Basel). 2022. PMID: 36422118 Free PMC article. Review.
-
Sasa veitchii extract reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet.Nagoya J Med Sci. 2017 Aug;79(3):279-290. doi: 10.18999/nagjms.79.3.279. Nagoya J Med Sci. 2017. PMID: 28878433 Free PMC article.
-
Lignosulfonate Rapidly Inactivates Human Immunodeficiency and Herpes Simplex Viruses.Medicines (Basel). 2021 Oct 3;8(10):56. doi: 10.3390/medicines8100056. Medicines (Basel). 2021. PMID: 34677485 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
