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Review
. 2013 Jul 1;18(7):7609-30.
doi: 10.3390/molecules18077609.

Hepatoprotective effects of mushrooms

Andréia Assunço Soares  1 , Anacharis Babeto de Sá-Nakanishi, Adelar Bracht, Sandra Maria Gomes da Costa, Eloá Angélica Koehnlein, Cristina Giatti Marques de Souza, Rosane Marina Peralta
Affiliations
Review

Hepatoprotective effects of mushrooms

Andréia Assunço Soares et al. Molecules. .

Abstract

The particular characteristics of growth and development of mushrooms in nature result in the accumulation of a variety of secondary metabolites such as phenolic compounds, terpenes and steroids and essential cell wall components such as polysaccharides, b-glucans and proteins, several of them with biological activities. The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this review, however, emphasis was given to studies using other mushrooms, especially those presenting efforts of attributing hepatoprotective activities to specific chemical components usually present in the mushroom extracts.

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Figures

Figure 1
Figure 1
General scheme used for the evaluation of hepato-protective effects of crude or semi-purified extracts and isolated molecules. Animals are treatedfor a specific periodwith a probablehepato-protectiveagent. A lesion is induced by introducing a hepatic damage-inducing agent. Several biomarkers of hepatotoxicity are evaluated in the liver and serum of treated and non-treated animals. TBARS: thiobarbituric acid reactive substances; ROS: reactive oxygen species; CAT: catalase, SOD: superoxide dismutase; GR: glutathione reductase; GPx: gluthatione peroxidase; NO: nitric oxide; GSH: glutathione; ALT: alanine aminotransferase; AST: aspartate aminotransferase; LDH: lactate dehydrogenase; AP: alkaline phosphatase.
Figure 2
Figure 2
Mushrooms (Ascomycota and Basidiomycota) used in hepatoprotective studies.
Figure 3
Figure 3
Two representative molecules obtained from mushrooms with hepatoprotective properties.
See this image and copyright information in PMC

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