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Case Reports
. 2013 Jun;9(2):218-20.
doi: 10.1007/s12024-013-9410-1. Epub 2013 Mar 16.

Lethal neuroleptic malignant syndrome due to amisulpride

Frank Musshoff  1 , Elke Doberentz, Burkhard Madea
Affiliations
Case Reports

Lethal neuroleptic malignant syndrome due to amisulpride

Frank Musshoff et al. Forensic Sci Med Pathol. 2013 Jun.

Abstract

A 42-year old-man was found lying in his bed having seizures. Later he became unconscious and hypotonic developing mydriasis as well as rigidity. The body core temperature (rectal temperature) was above 42 °C. Blood pH was decreased during treatment, and his general condition deteriorated. The patient developed gasping respiration, ventricular fibrillation, and died. During autopsy and histological investigation cerebral and pulmonary edema were noted together with general congestion of the internal organs. Further observations included contraction bands of myocytes, a contracted spleen, fibrosis of the liver, and gall stones. Toxicological analyses of peripheral blood revealed the following results: amisulpride 4.65 mg/l, biperiden 0.12 mg/l, imipramine 0.33 mg/l, and desipramine 0.68 mg/l. An amisulpride-induced neuroleptic malignant syndrome was therefore diagnosed as the patho-physiological mechanism leading to death.

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References

    1. Am J Psychiatry. 1985 Oct;142(10):1137-45 - PubMed
    1. Am J Psychiatry. 1986 Oct;143(10):1227-33 - PubMed
    1. Chang Gung Med J. 2011 Sep-Oct;34(5):536-40 - PubMed
    1. Drugs. 2001;61(14):2123-50 - PubMed
    1. J Clin Psychiatry. 2004 Dec;65(12):1724-5 - PubMed

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