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. 2008 Jan;36(Database issue):D901-6.
doi: 10.1093/nar/gkm958. Epub 2007 Nov 29.

DrugBank: a knowledgebase for drugs, drug actions and drug targets

David S Wishart  1 , Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, Murtaza Hassanali
Affiliations

DrugBank: a knowledgebase for drugs, drug actions and drug targets

David S Wishart et al. Nucleic Acids Res. 2008 Jan.

Abstract

DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in 2006, DrugBank has been widely used to facilitate in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmaceutical education. The latest version of DrugBank (release 2.0) has been expanded significantly over the previous release. With approximately 4900 drug entries, it now contains 60% more FDA-approved small molecule and biotech drugs including 10% more 'experimental' drugs. Significantly, more protein target data has also been added to the database, with the latest version of DrugBank containing three times as many non-redundant protein or drug target sequences as before (1565 versus 524). Each DrugCard entry now contains more than 100 data fields with half of the information being devoted to drug/chemical data and the other half devoted to pharmacological, pharmacogenomic and molecular biological data. A number of new data fields, including food-drug interactions, drug-drug interactions and experimental ADME data have been added in response to numerous user requests. DrugBank has also significantly improved the power and simplicity of its structure query and text query searches. DrugBank is available at http://www.drugbank.ca.

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Figures

Figure 1.
Figure 1.
A screenshot montage of some of DrugBank's new or modified querying tools including ChemQuery, TextQuery and an example of the new generic text query output.
See this image and copyright information in PMC

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