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. 2006 Sep;79(3):544-8.
doi: 10.1086/506913. Epub 2006 Jun 28.

Navajo neurohepatopathy is caused by a mutation in the MPV17 gene

Charalampos L Karadimas  1 , Tuan H Vu, Stephen A Holve, Penelope Chronopoulou, Catarina Quinzii, Stanley D Johnsen, Janice Kurth, Elizabeth Eggers, Lluis Palenzuela, Kurenai Tanji, Eduardo Bonilla, Darryl C De Vivo, Salvatore DiMauro, Michio Hirano
Affiliations

Navajo neurohepatopathy is caused by a mutation in the MPV17 gene

Charalampos L Karadimas et al. Am J Hum Genet. 2006 Sep.

Abstract

Navajo neurohepatopathy (NNH) is an autosomal recessive disease that is prevalent among Navajo children in the southwestern United States. The major clinical features are hepatopathy, peripheral neuropathy, corneal anesthesia and scarring, acral mutilation, cerebral leukoencephalopathy, failure to thrive, and recurrent metabolic acidosis with intercurrent infections. Infantile, childhood, and classic forms of NNH have been described. Mitochondrial DNA (mtDNA) depletion was detected in the livers of two patients, suggesting a primary defect in mtDNA maintenance. Homozygosity mapping of two families with NNH suggested linkage to chromosome 2p24. This locus includes the MPV17 gene, which, when mutated, causes a hepatocerebral form of mtDNA depletion. Sequencing of the MPV17 gene in six patients with NNH from five families revealed the homozygous R50Q mutation described elsewhere. Identification of a single missense mutation in patients with NNH confirms that the disease is probably due to a founder effect and extends the phenotypic spectrum associated with MPV17 mutations.

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Figures

Figure 1.
Figure 1.
Families 1–5 with NNH. Family 1 was described by Singleton et al. and by Holve et al. The probands in families 4 (II-1) and 5 (II-1) were reported as patients 1 and 2, respectively, by Vu et al. The nucleotide 149G→A transition in the MPV17 gene is denoted by a plus sign (+), and the normal sequence is denoted by a minus sign (−).
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References

Web Resource

    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim (for NNH, DGUOK, TK2, SUCLA2, POLG, TFAM, NRF-1, ENDOG, MPV17, and Alpers syndrome)

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