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Review
. 2006 Apr;95(451):57-62.
doi: 10.1111/j.1651-2227.2006.tb02391.x.

Magnetic resonance imaging changes in Fabry disease

Lionel Ginsberg  1 , Renzo Manara, Alan R Valentine, Brian Kendall, Alessandro P Burlina
Affiliations
Review

Magnetic resonance imaging changes in Fabry disease

Lionel Ginsberg et al. Acta Paediatr Suppl. 2006 Apr.

Abstract

Recognized magnetic resonance imaging (MRI) abnormalities in the brains of patients with Fabry disease include the consequences of infarction and haemorrhage, non-specific white and grey matter lesions, vascular anomalies, in particular dolicho-ectasia, and a characteristic appearance of the posterior thalamus. A preliminary analysis of MRI findings in patients registered in FOS, the Fabry Outcome Survey, indicates that most patients had abnormal scans (25/47). The commonest abnormality, in males and females, was the presence of cerebral white matter lesions, the number of which increased with patient age.

Conclusion: MRI is a valuable resource for assessing the CNS complications of Fabry disease, and their response to time and treatment.

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