Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system
- PMID: 14598369
- DOI: 10.1002/neu.10283
Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system
Abstract
Microtubule-associated protein 1B is the first MAP to be expressed during the development of the nervous system. Several different approaches have revealed that MAP1B function is associated with microtubule and actin microfilament polymerization and dynamics. In recent years, the generation of molecular models to inactivate MAP1B function in invertebrates and mammals has sparked some controversy about the real role of MAP1B. Despite discrepancies between some studies, it is clear that MAP1B plays a principal role in the development of the nervous system. In this article, we summarize the evidence for MAP1B function in a wide variety of cellular processes implicated in the proper construction of the nervous system. We also discuss the role of MAP1B in pathological processes.
Copyright 2003 Wiley Periodicals, Inc. J Neurobiol 58: 48-59, 2004
Similar articles
-
Microtubule-associated protein 1B, a growth-associated and phosphorylated scaffold protein.Brain Res Bull. 2007 Mar 30;71(6):541-58. doi: 10.1016/j.brainresbull.2006.11.012. Epub 2006 Dec 27. Brain Res Bull. 2007. PMID: 17292797 Review.
-
Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination.Dev Neurosci. 2008;30(1-3):200-10. doi: 10.1159/000109863. Dev Neurosci. 2008. PMID: 18075266
-
Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels.Mol Cell Neurosci. 2000 Oct;16(4):408-21. doi: 10.1006/mcne.2000.0880. Mol Cell Neurosci. 2000. PMID: 11085878
-
MAP1B expression and microtubule stability in growing and regenerating axons.Microsc Res Tech. 2000 Jan 15;48(2):63-74. doi: 10.1002/(SICI)1097-0029(20000115)48:2<63::AID-JEMT2>3.0.CO;2-1. Microsc Res Tech. 2000. PMID: 10649507 Review.
-
Expression of MAP1B protein and its phosphorylated form MAP1B-P in the CNS of a continuously growing fish, the rainbow trout.Brain Res. 2004 May 29;1009(1-2):54-66. doi: 10.1016/j.brainres.2004.02.043. Brain Res. 2004. PMID: 15120583
Cited by
-
Initiating and growing an axon.Cold Spring Harb Perspect Biol. 2010 Apr;2(4):a001925. doi: 10.1101/cshperspect.a001925. Cold Spring Harb Perspect Biol. 2010. PMID: 20452947 Free PMC article. Review.
-
Global protein differential expression profiling of cerebrospinal fluid samples pooled from Chinese sporadic CJD and non-CJD patients.Mol Neurobiol. 2014 Feb;49(1):290-302. doi: 10.1007/s12035-013-8519-2. Epub 2013 Aug 4. Mol Neurobiol. 2014. PMID: 23912784
-
Induction of autophagy in axonal dystrophy and degeneration.J Neurosci. 2006 Aug 2;26(31):8057-68. doi: 10.1523/JNEUROSCI.2261-06.2006. J Neurosci. 2006. PMID: 16885219 Free PMC article.
-
De novo and inherited private variants in MAP1B in periventricular nodular heterotopia.PLoS Genet. 2018 May 8;14(5):e1007281. doi: 10.1371/journal.pgen.1007281. eCollection 2018 May. PLoS Genet. 2018. PMID: 29738522 Free PMC article.
-
Establishment of axon-dendrite polarity in developing neurons.Annu Rev Neurosci. 2009;32:347-81. doi: 10.1146/annurev.neuro.31.060407.125536. Annu Rev Neurosci. 2009. PMID: 19400726 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
