Review
doi: 10.1016/s1367-5931(03)00027-9.
Missing genes in metabolic pathways: a comparative genomics approach
Affiliations
- PMID: 12714058
- DOI: 10.1016/s1367-5931(03)00027-9
Item in Clipboard
Review
Missing genes in metabolic pathways: a comparative genomics approach
Curr Opin Chem Biol.
2003 Apr.
Abstract
The new techniques of genome context analysis--chromosomal gene clustering, protein fusions, occurrence profiles and shared regulatory sites--infer functional coupling between genes. In combination with metabolic reconstructions, these techniques can dramatically accelerate the pace of gene discovery.
Similar articles
-
Using gene knockouts to investigate plant metabolism.J Exp Bot. 2001 Aug;52(361):1593-601. J Exp Bot. 2001. PMID: 11479324 Review.
-
Metabolic gene clusters encoding the enzymes of two branches of the 3-oxoadipate pathway in the pathogenic yeast Candida albicans.FEMS Yeast Res. 2015 May;15(3):fov006. doi: 10.1093/femsyr/fov006. Epub 2015 Mar 4. FEMS Yeast Res. 2015. PMID: 25743787
-
New compounds by combining "modern" genomics and "old-fashioned" mutasynthesis.Chem Biol. 2002 Nov;9(11):1163-4. doi: 10.1016/s1074-5521(02)00267-3. Chem Biol. 2002. PMID: 12445765 No abstract available.
-
Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs.BMC Genomics. 2003 Jun 3;4(1):22. doi: 10.1186/1471-2164-4-22. Epub 2003 Jun 3. BMC Genomics. 2003. PMID: 12783626 Free PMC article.
-
Genome mining as a biotechnological tool for the discovery of novel marine natural products.Crit Rev Biotechnol. 2020 Aug;40(5):571-589. doi: 10.1080/07388551.2020.1751056. Epub 2020 Apr 19. Crit Rev Biotechnol. 2020. PMID: 32308042 Review.
Cited by
-
Current opportunities and challenges in microbial metagenome analysis--a bioinformatic perspective.Brief Bioinform. 2012 Nov;13(6):728-42. doi: 10.1093/bib/bbs039. Epub 2012 Sep 9. Brief Bioinform. 2012. PMID: 22966151 Free PMC article. Review.
-
The CanOE strategy: integrating genomic and metabolic contexts across multiple prokaryote genomes to find candidate genes for orphan enzymes.PLoS Comput Biol. 2012 May;8(5):e1002540. doi: 10.1371/journal.pcbi.1002540. Epub 2012 May 31. PLoS Comput Biol. 2012. PMID: 22693442 Free PMC article.
-
Predicting genes for orphan metabolic activities using phylogenetic profiles.Genome Biol. 2006;7(2):R17. doi: 10.1186/gb-2006-7-2-r17. Epub 2006 Feb 15. Genome Biol. 2006. PMID: 16507154 Free PMC article.
-
Inter-genomic displacement via lateral gene transfer of bacterial trp operons in an overall context of vertical genealogy.BMC Biol. 2004 Jun 23;2:15. doi: 10.1186/1741-7007-2-15. BMC Biol. 2004. PMID: 15214963 Free PMC article.
-
From complete genome sequence to 'complete' understanding?Trends Biotechnol. 2010 Aug;28(8):398-406. doi: 10.1016/j.tibtech.2010.05.006. Trends Biotechnol. 2010. PMID: 20647113 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
