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Review
. 2002 Dec;110(11):1579-83.
doi: 10.1172/JCI16787.

Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury

David H Perlmutter  1
Affiliations
Review

Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury

David H Perlmutter. J Clin Invest. 2002 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Schematic model of events that characterize the autophagic response. Adapted from ref. with permission.
Figure 2
Figure 2
Autophagic vacuoles in fibroblasts engineered for expression of mutant α1ATZ. Transmission electron micrograph shows nascent autophagosomes (AVi) and degradative autophagosomes (AVd) intercalated within and around cisternae of rough ER (rER) that is dilated with granular material. N, nucleus; M, mitochondrion. Reproduced from ref. with permission.
Figure 3
Figure 3
Autophagic vacuoles in human liver tissue. Transmission electron micrograph of a liver biopsy specimen from an individual homozygous for α1ATZ is shown. (a) One of the relatively normal hepatocytes that can be seen in such livers. (b) A hepatocyte with markedly dilated rough ER (rER). (c) An autophagic vacuole evolving adjacent to rER. (d) Nascent autophagosomes; (e) degradative autophagosomes. Bar, 100 nm. Taken from ref. with permission.
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