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Review
. 2002 Apr 4;416(6880):499-506.
doi: 10.1038/416499a.

An extensive network of coupling among gene expression machines

Tom Maniatis  1 , Robin Reed
Affiliations
Review

An extensive network of coupling among gene expression machines

Tom Maniatis et al. Nature. .

Abstract

Gene expression in eukaryotes requires several multi-component cellular machines. Each machine carries out a separate step in the gene expression pathway, which includes transcription, several pre-messenger RNA processing steps and the export of mature mRNA to the cytoplasm. Recent studies lead to the view that, in contrast to a simple linear assembly line, a complex and extensively coupled network has evolved to coordinate the activities of the gene expression machines. The extensive coupling is consistent with a model in which the machines are tethered to each other to form 'gene expression factories' that maximize the efficiency and specificity of each step in gene expression.

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