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. 2002 Jan;19(1):80-1.
doi: 10.1002/humu.9001.

Mutation analysis of the FAH gene in Israeli patients with tyrosinemia type I

Orly N Elpeleg  1 , Avraham Shaag, Elizabeth Holme, Ghaleb Zughayar, Suzi Ronen, Drora Fisher, Haggit Hurvitz
Affiliations

Mutation analysis of the FAH gene in Israeli patients with tyrosinemia type I

Orly N Elpeleg et al. Hum Mutat. 2002 Jan.

Abstract

Thirteen Israeli patients with type I tyrosinemia were studied. To the best of our knowledge, this group represents all of the patients that were diagnosed in Israel during the years 1987-1997. Their age of onset was variable but all the patients suffered from liver disease at presentation. Six died at 3 to 36 months of age, whereas the remaining 7, in whom NTBC was started at 5 to 30 months, are alive and well at 4 to 11 years. Three mutations were identified: a mis-splicing IVS8-1G>C mutation in a large Moslem kindred, Pro261Leu mutation in all Jewish patients, and the IVS12+5G>A mutation, commonly found in French Canadian patients.

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