Genotype and severity of long QT syndrome
Affiliations
- PMID: 11259355
Item in Clipboard
Genotype and severity of long QT syndrome
Drug Metab Dispos.
2001 Apr.
Abstract
Sudden cardiac death occurs in the United States with an incidence greater than 300,000 persons per year. The underlying cause of death is commonly considered to be due to primary or secondary arrhythmias. In cases in which no structural heart disease can be identified, the long QT syndromes (LQTS) are now commonly considered as likely causes. Multiple genes causing LQTS have been identified thus far, all encoding cardiac ion channels. These include two potassium channel alpha-subunits (KVLQT1, HERG), two potassium channel beta-subunits (minK, MiRP1), and one sodium channel gene (SCN5A). The purpose of this review is to describe the current understanding of the molecular genetics of LQTS and the resultant phenotypes.
Similar articles
-
Current concepts in long QT syndrome.Pediatr Cardiol. 2000 Nov-Dec;21(6):542-50. doi: 10.1007/s002460010132. Pediatr Cardiol. 2000. PMID: 11050278 Review.
-
[Molecular genetics of the long QT syndrome: clinical aspects].Orv Hetil. 1999 Nov 21;140(47):2633-8. Orv Hetil. 1999. PMID: 10613047 Review. Hungarian.
-
Genetics, molecular mechanisms and management of long QT syndrome.Ann Med. 1998 Feb;30(1):58-65. doi: 10.3109/07853899808999385. Ann Med. 1998. PMID: 9556090 Review.
-
[Molecular genetics in the hereditary form of long QT syndrome].Med Pregl. 2000 Jan-Feb;53(1-2):51-4. Med Pregl. 2000. PMID: 10953551 Review. Croatian.
-
The molecular genetics of the long QT syndrome: genes causing fainting and sudden death.Annu Rev Med. 1998;49:263-74. doi: 10.1146/annurev.med.49.1.263. Annu Rev Med. 1998. PMID: 9509262 Review.
Cited by
-
Novel compound heterozygous mutations in the KCNQ1 gene associated with autosomal recessive long QT syndrome (Jervell and Lange-Nielsen syndrome).Ann Noninvasive Electrocardiol. 2003 Jul;8(3):246-50. doi: 10.1046/j.1542-474x.2003.08313.x. Ann Noninvasive Electrocardiol. 2003. PMID: 14510661 Free PMC article.
-
Pharmacogenetic tactics and strategies: implications for paediatrics.Paediatr Drugs. 2001;3(12):863-81. doi: 10.2165/00128072-200103120-00001. Paediatr Drugs. 2001. PMID: 11772149 Review.
-
Mutation analysis of KCNQ1, KCNH2, SCN5A, KCNE1 and KCNE2 genes in Chinese patients with long QT syndrome.Front Med China. 2007 Jul;1(3):312-5. doi: 10.1007/s11684-007-0060-0. Epub 2007 Jul 1. Front Med China. 2007. PMID: 24573873
-
Are hERG channel blockers also phospholipidosis inducers?Bioorg Med Chem Lett. 2013 Aug 15;23(16):4587-90. doi: 10.1016/j.bmcl.2013.06.034. Epub 2013 Jun 20. Bioorg Med Chem Lett. 2013. PMID: 23856051 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Miscellaneous