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Case Reports
. 2000 Nov;83(5):439-42.
doi: 10.1136/adc.83.5.439.

Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis

S M Gospe Jr  1 , R D Caruso, M S Clegg, C L Keen, N R Pimstone, J M Ducore, S S Gettner, R A Kreutzer
Affiliations
Case Reports

Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis

S M Gospe Jr et al. Arch Dis Child. 2000 Nov.

Abstract

Progressive myelopathy is a rare complication of chronic hepatic disease which has never been reported in the paediatric age group. We describe the 11 year course of an adolescent male with hepatic myelopathy caused by cryptogenic micronodular cirrhosis. His condition has been associated with persistent polycythaemia and extraordinary increases of whole blood manganese, with magnetic resonance imaging evidence of manganese deposition within the basal ganglia and other regions of the brain. The patient has developed neither liver failure nor parkinsonism. The pathophysiological bases of this multiorgan system disorder are described.

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References

    1. Neuroradiology. 1997 Aug;39(8):546-50 - PubMed
    1. Nature. 1997 Jul 31;388(6641):482-8 - PubMed
    1. N Engl J Med. 1999 Jan 14;340(2):151 - PubMed
    1. Gastroenterology. 1999 Sep;117(3):640-4 - PubMed
    1. Blood. 1999 Sep 15;94(6):1864-77 - PubMed

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