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• Enzyme replacement with PEGylated cystathionine β-synthase ameliorates homocystinuria in murine model.

  Bublil EM, Majtan T, Park I, Carrillo RS, Hůlková H, Krijt J, Kožich V, Kraus JP. Bublil EM, et al. J Clin Invest. 2016 Jun 1;126(6):2372-84. doi: 10.1172/JCI85396. Epub 2016 May 16. J Clin Invest. 2016. PMID: 27183385 Free PMC article.
• Hyperhomocysteinemia is one of the risk factors associated with cerebrovascular stiffness in hypertensive patients, especially elderly males.

  Okura T, Miyoshi K, Irita J, Enomoto D, Nagao T, Kukida M, Tanino A, Kudo K, Pei Z, Higaki J. Okura T, et al. Sci Rep. 2014 Jul 11;4:5663. doi: 10.1038/srep05663. Sci Rep. 2014. PMID: 25012721 Free PMC article.
• Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways.

  Werstuck GH, Lentz SR, Dayal S, Hossain GS, Sood SK, Shi YY, Zhou J, Maeda N, Krisans SK, Malinow MR, Austin RC. Werstuck GH, et al. J Clin Invest. 2001 May;107(10):1263-73. doi: 10.1172/JCI11596. J Clin Invest. 2001. PMID: 11375416 Free PMC article.
• Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury.

  Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J, Kong W. Li T, et al. Nat Commun. 2018 Jan 2;9(1):11. doi: 10.1038/s41467-017-02401-7. Nat Commun. 2018. PMID: 29296021 Free PMC article.
• Trends in clinical laboratory homocysteine testing from 1997 to 2010: the impact of evidence on clinical practice at a single institution.

  Klykov CM, Lentz SR. Klykov CM, et al. Clin Chem Lab Med. 2013 Mar 1;51(3):671-5. doi: 10.1515/cclm-2012-0637. Clin Chem Lab Med. 2013. PMID: 23152416 Free PMC article.