Review
[Pathogenesis of porphyria cutanea tarda]
[Article in
Hungarian]
Affiliations
- PMID: 10803012
Item in Clipboard
Review
[Pathogenesis of porphyria cutanea tarda]
[Article in
Hungarian]
Orv Hetil.
.
Abstract
Porphyria cutanea tarda (PCT) results basically from decreased activity of uroporphyrinogen decarboxylase (UROD) in the liver. PCT is not a homogeneous disease; it can be either inherited or acquired. Not only alterations at the UROD gen locus but also other genetic factors outside the locus take part in the inactivation of UROD, that support polygenic inheritance of PCT. In every case, acquired factors take also part in development of the overt form of PCT. Iron has a key-role in the oxidative damages.
Similar articles
-
Porphyria cutanea tarda.Semin Liver Dis. 1998;18(1):67-75. doi: 10.1055/s-2007-1007142. Semin Liver Dis. 1998. PMID: 9516680 Review.
-
Haem biosynthesis and human porphyria cutanea tarda: effects of alcohol intake.Indian J Exp Biol. 2000 Jul;38(7):635-42. Indian J Exp Biol. 2000. PMID: 11215304 Review.
-
Hepatic uroporphyrinogen decarboxylase activity in porphyria cutanea tarda patients: the influence of virus C infection.Hepatology. 1998 Feb;27(2):584-9. doi: 10.1002/hep.510270237. Hepatology. 1998. PMID: 9462661
-
Porphyria cutanea tarda--when skin meets liver.Best Pract Res Clin Gastroenterol. 2010 Oct;24(5):735-45. doi: 10.1016/j.bpg.2010.07.002. Best Pract Res Clin Gastroenterol. 2010. PMID: 20955974 Review.
-
Molecular heterogeneity of familial porphyria cutanea tarda in Spain: characterization of 10 novel mutations in the UROD gene.Br J Dermatol. 2007 Sep;157(3):501-7. doi: 10.1111/j.1365-2133.2007.08064.x. Epub 2007 Jul 11. Br J Dermatol. 2007. PMID: 17627795