Review
doi: 10.1016/s0959-440x(99)00057-3.
Winged helix proteins
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- PMID: 10679470
- DOI: 10.1016/s0959-440x(99)00057-3
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Review
Winged helix proteins
Curr Opin Struct Biol.
2000 Feb.
Abstract
The winged helix proteins constitute a subfamily within the large ensemble of helix-turn-helix proteins. Since the discovery of the winged helix/fork head motif in 1993, a large number of topologically related proteins with diverse biological functions have been characterized by X-ray crystallography and solution NMR spectroscopy. Recently, a winged helix transcription factor (RFX1) was shown to bind DNA using unprecedented interactions between one of its eponymous wings and the major groove. This surprising observation suggests that the winged helix proteins can be subdivided into at least two classes with radically different modes of DNA recognition.
Comment in
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Protein-nucleic acid interactions.Curr Opin Struct Biol. 2000 Feb;10(1):75-7. doi: 10.1016/s0959-440x(99)00052-4. Curr Opin Struct Biol. 2000. PMID: 10766517 Review. No abstract available.
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