Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2
- PMID: 10617615
- DOI: 10.1074/jbc.275.1.271
Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2
Abstract
Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is an intracellular protein involved in signal transduction from TNF receptor I and II and related receptors. TRAF2 is required for TNF-induced activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), and TRAF2 can also mediate activation of NF-kappaB. Here we have identified the actin-binding protein Filamin (actin-binding protein-280) as a TRAF2-interacting protein. Filamin binds to the Ring zinc finger domain of TRAF2. Overexpressed Filamin inhibits TRAF2-induced activation of JNK/SAPK and of NF-kappaB. Furthermore, ectopically expressed Filamin inhibits NF-kappaB activation induced via TNF, interleukin-1, Toll receptors, and TRAF6 but not activation induced via overexpression of NIK, a downstream effector in these pathways. Importantly, TNF fails to activate SAPK or NF-kappaB in a human melanoma cell line deficient in Filamin. Reintroduction of Filamin into these cells restores the TNF response. The data imply a role for Filamin in inflammatory signal transduction pathways.
Similar articles
-
CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase.J Biol Chem. 1998 May 22;273(21):13353-8. doi: 10.1074/jbc.273.21.13353. J Biol Chem. 1998. PMID: 9582383
-
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.J Biol Chem. 1999 Mar 19;274(12):7724-31. doi: 10.1074/jbc.274.12.7724. J Biol Chem. 1999. PMID: 10075662
-
Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/stress-activated protein kinase.J Biol Chem. 1997 Oct 17;272(42):26079-82. doi: 10.1074/jbc.272.42.26079. J Biol Chem. 1997. PMID: 9334169
-
NF-kappa B activation by tumor necrosis factor and interleukin-1.Cold Spring Harb Symp Quant Biol. 1999;64:473-83. doi: 10.1101/sqb.1999.64.473. Cold Spring Harb Symp Quant Biol. 1999. PMID: 11232324 Review. No abstract available.
-
Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways.Front Immunol. 2018 Aug 9;9:1849. doi: 10.3389/fimmu.2018.01849. eCollection 2018. Front Immunol. 2018. PMID: 30140268 Free PMC article. Review.
Cited by
-
Sphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor Microenvironment.Front Oncol. 2016 Oct 17;6:218. doi: 10.3389/fonc.2016.00218. eCollection 2016. Front Oncol. 2016. PMID: 27800303 Free PMC article. Review.
-
Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling.Mol Cell Biol. 2015 Nov 9;36(2):320-9. doi: 10.1128/MCB.00554-15. Print 2016 Jan 15. Mol Cell Biol. 2015. PMID: 26552704 Free PMC article.
-
How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members?Immunol Rev. 2011 Nov;244(1):29-43. doi: 10.1111/j.1600-065X.2011.01060.x. Immunol Rev. 2011. PMID: 22017429 Free PMC article. Review.
-
Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt.Mol Cell Biol. 2011 Apr;31(8):1710-8. doi: 10.1128/MCB.00939-10. Epub 2011 Feb 7. Mol Cell Biol. 2011. PMID: 21300786 Free PMC article.
-
Actin networks modulate heterogeneous NF-κB dynamics in response to TNFα.Elife. 2024 Aug 7;13:e86042. doi: 10.7554/eLife.86042. Elife. 2024. PMID: 39110005 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
