doi: 10.1007/s001090050369.
Conserved transactivation domain shared by interferon regulatory factors and Smad morphogens
Affiliations
- PMID: 10426188
- DOI: 10.1007/s001090050369
Item in Clipboard
Conserved transactivation domain shared by interferon regulatory factors and Smad morphogens
J Mol Med (Berl).
1999 May.
Abstract
Interferon regulatory factors (IRFs) regulate the transcription of both interferon-inducible genes and interferons themselves. Along with the N-terminal, DNA-binding, winged-helix domain, most IRFs contain the C-terminal domains that are shown to be related to the C-terminal domains in the proteins of the Smad family that mediate transcription activation in the transforming growth factor response pathway. Comparison of the IRF-Smad alignment to the known three-dimensional structure of human tumor suppressor Smad4 suggests that a conserved loop, equivalent to Loop 3 in Smad 4, is a determinant of protein-protein interaction in IRFs.
Similar articles
-
Functional dissection of the transactivation domain of interferon regulatory factor-1.Biochem Biophys Res Commun. 2003 May 2;304(2):253-9. doi: 10.1016/s0006-291x(03)00575-8. Biochem Biophys Res Commun. 2003. PMID: 12711307
-
Interferon regulatory factors: the next generation.Gene. 1999 Sep 3;237(1):1-14. doi: 10.1016/s0378-1119(99)00262-0. Gene. 1999. PMID: 10524230 Review.
-
Cloning of an interferon regulatory factor 2 isoform with different regulatory ability.Nucleic Acids Res. 2000 Nov 1;28(21):4219-24. doi: 10.1093/nar/28.21.4219. Nucleic Acids Res. 2000. PMID: 11058120 Free PMC article.
-
Crystal structure of a transcriptionally active Smad4 fragment.Structure. 1999 Dec 15;7(12):1493-503. doi: 10.1016/s0969-2126(00)88340-9. Structure. 1999. PMID: 10647180
-
Activities of IRF-1.J Interferon Cytokine Res. 2002 Jan;22(1):5-14. doi: 10.1089/107999002753452610. J Interferon Cytokine Res. 2002. PMID: 11846971 Review.
Cited by
-
Rotavirus NSP1 mediates degradation of interferon regulatory factors through targeting of the dimerization domain.J Virol. 2013 Sep;87(17):9813-21. doi: 10.1128/JVI.01146-13. Epub 2013 Jul 3. J Virol. 2013. PMID: 23824805 Free PMC article.
-
Characterization of common carp (Cyprinus carpio L.) interferon regulatory factor 5 (IRF5) and its expression in response to viral and bacterial challenges.BMC Vet Res. 2016 Jun 27;12(1):127. doi: 10.1186/s12917-016-0750-4. BMC Vet Res. 2016. PMID: 27350041 Free PMC article.
-
Identification of an IRF10 gene in common carp (Cyprinus carpio L.) and analysis of its function in the antiviral and antibacterial immune response.BMC Vet Res. 2020 Nov 19;16(1):450. doi: 10.1186/s12917-020-02674-z. BMC Vet Res. 2020. PMID: 33213475 Free PMC article.
-
Molecular identification and functional characterization of IRF4 from common carp (Cyprinus carpio. L) in immune response: a negative regulator in the IFN and NF-κB signalling pathways.BMC Vet Res. 2022 Mar 17;18(1):106. doi: 10.1186/s12917-022-03205-8. BMC Vet Res. 2022. PMID: 35300694 Free PMC article.
-
IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer.EMBO J. 2008 Oct 22;27(20):2639-47. doi: 10.1038/emboj.2008.196. Epub 2008 Sep 25. EMBO J. 2008. PMID: 18818691 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
