{"id":12024,"date":"2023-08-29T13:23:55","date_gmt":"2023-08-29T17:23:55","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=12024"},"modified":"2023-08-29T14:01:33","modified_gmt":"2023-08-29T18:01:33","slug":"animals-catch-transmit-human-viral-infections","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/08\/29\/animals-catch-transmit-human-viral-infections\/","title":{"rendered":"Which animals can catch and transmit human viral infections?"},"content":{"rendered":"

Using the NIH Comparative Genomics Resource (CGR) to understand susceptibility <\/span>to<\/span> SARS-CoV-2<\/span> and other <\/span>infection<\/span>s<\/span><\/span>\u00a0<\/span><\/em><\/h3>\n

Are you conducting research on animal-mediated transmission of human viral infections, such as COVID-19? The National Institutes of Health (NIH) <\/span>Comparative Genomics Resource (CGR)<\/span><\/a> offers a cutting-edge NCBI toolkit of high-quality genomics data and tools to help with comparative genomics analysis for eukaryotic genes, such as <\/span>Angiotensin-converting enzyme 2 (ACE2)<\/span> which is targeted by SARS-CoV-2.\u00a0<\/span>\u00a0<\/span><\/p>\n

NCBI resources have been beneficial in helping the scientific community understand viral infections associated with public health crises, such as COVID-19 and Influenza, and can be used for study of emerging viruses that may represent new threats.\u00a0<\/span>\u00a0<\/span><\/p>\n

How and why should you use our resources? Consider the example below!<\/h5>\n

Early in the COVID-19 pandemic, comparative genomics <\/span>(<\/span>example<\/span><\/a>) <\/span>was used to identify a range of animals potentially infected by SARS-CoV-2 by targeting their ACE2 protein, a cellular receptor for viral entry into host cells. These species represented both potential routes of transmission and new animal models to study SARS-CoV-2 infections in humans.\u00a0<\/span>\u00a0<\/span><\/p>\n

The following are relevant CGR and other NCBI resources that can help with your research on ACE2 genes with example records and search results.<\/span><\/p>\n\n\n\n\n\n\n\n
\"Abstract<\/td>\nCompare ACE2 genomic regions in humans and bats<\/a> with the Comparative Genome Viewer (CGV)<\/td>\n<\/tr>\n
\"Three<\/td>\nExamine human and bat ACE2 genomic regions alongside other annotation tracks<\/span><\/a> with the Genome Data Viewer (GDV)\u00a0\u00a0<\/span>\u00a0<\/span><\/td>\n<\/tr>\n
\"drawing<\/td>\nSearch with a bat ACE2 protein to identify similar sequences<\/span><\/a> in animals that can be found near humans, such as pigs, rabbits, and guinea pigs,<\/span> using<\/span> BLAST with the ClusteredNR Database<\/span>\u00a0<\/span><\/td>\n<\/tr>\n
\"circle<\/td>\nExplore and compare ACE2 ortholog sequences<\/span><\/a> of other animals such <\/span>as<\/span>\u00a0bearded dragons,<\/span><\/a> goldfish,<\/span><\/a> and <\/span>parrots<\/span><\/a> with NCBI Orthologs and their protein alignments <\/span>\u00a0<\/span><\/td>\n<\/tr>\n
\"image<\/td>\nAssess and download genome assemblies<\/span><\/a> for a custom set of organisms<\/span>, such as those listed above, using NCBI Datasets<\/span>\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Stay up to date<\/h5>\n

Join our <\/span>mailing list<\/span><\/a> to stay up to date on CGR news. If you\u2019re interested in getting involved, reach out to us at cgr@nlm.nih.gov or visit <\/span>our website<\/span><\/a> and click the yellow Feedback button on the bottom right.\u00a0\u00a0<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Using the NIH Comparative Genomics Resource (CGR) to understand susceptibility to SARS-CoV-2 and other infections\u00a0 Are you conducting research on animal-mediated transmission of human viral infections, such as COVID-19? The National Institutes of Health (NIH) Comparative Genomics Resource (CGR) offers a cutting-edge NCBI toolkit of high-quality genomics data and tools to help with comparative genomics … Continue reading Which animals can catch and transmit human viral infections?<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":12026,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"Which animals can catch and transmit human viral infections?","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[77187,693060769,693060768,693060686,574293891],"table_tags":[],"class_list":["post-12024","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-blast","tag-comparative-genome-viewer-cgv","tag-comparative-genomics-resource-cgr","tag-datasets","tag-genome-data-viewer"],"jetpack_publicize_connections":[],"yoast_head":"\nWhich animals can catch and transmit human viral infections? - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/08\/29\/animals-catch-transmit-human-viral-infections\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Which animals can catch and transmit human viral infections? - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"Using the NIH Comparative Genomics Resource (CGR) to understand susceptibility to SARS-CoV-2 and other infections\u00a0 Are you conducting research on animal-mediated transmission of human viral infections, such as COVID-19? 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