{"id":11188,"date":"2023-04-24T09:57:01","date_gmt":"2023-04-24T13:57:01","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=11188"},"modified":"2023-04-24T09:57:01","modified_gmt":"2023-04-24T13:57:01","slug":"hmm-release-12-0","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/","title":{"rendered":"NCBI Hidden Markov Models (HMM) Release 12.0 Now Available!"},"content":{"rendered":"<p>Release 12.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/genome\/annotation_prok\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=hmm-release-12-20230424\">Prokaryotic Genome Annotation Pipeline<\/a> (PGAP) is now available for <a href=\"https:\/\/ftp.ncbi.nlm.nih.gov\/hmm\/12.0\/\">download<\/a>. You can search this collection against your favorite prokaryotic proteins to identify their function using the <a href=\"http:\/\/eddylab.org\/software\/hmmer\/Userguide.pdf\">HMMER<\/a> sequence analysis package.<\/p>\n<h5>What&#8217;s new?<\/h5>\n<p>The 12.0 release contains:<\/p>\n<ul>\n<li>15,849 HMMs maintained by NCBI<\/li>\n<li>271 new HMMs since release 11.0<\/li>\n<li>1,248 HMMs with better names, EC numbers, <a href=\"http:\/\/geneontology.org\/\">Gene Ontology<\/a> (GO) terms, gene symbols or publications<\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p>You can search and view the details for these in the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/protfam?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=hmm-release-12-20230424\">Protein Family Model<\/a> collection, which also includes conserved domain architectures and BlastRules, and find all <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/refseq\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=hmm-release-12-20230424\">RefSeq<\/a> proteins these name.<\/p>\n<p>GO terms associated with HMMs are now propagated to CDSs and proteins annotated with PGAP. In case you missed it, see our <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2022\/02\/24\/gene-ontology-refseq\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=hmm-release-12-20230424\">previous blog post<\/a> on this topic.<\/p>\n<h5>Stay up to date<\/h5>\n<p><span data-contrast=\"auto\">Follow us on Twitter\u202f<\/span><a href=\"https:\/\/twitter.com\/ncbi\"><span data-contrast=\"auto\">@NCBI<\/span><\/a><span data-contrast=\"auto\">\u202fand\u202f<\/span><a href=\"https:\/\/public.govdelivery.com\/accounts\/USNLMOCPL\/subscriber\/new?topic_id=USNLMOCPL_52\"><span data-contrast=\"auto\">join our mailing list<\/span><\/a><span data-contrast=\"auto\">\u202fto keep up to date with\u202fHMM\u202fand other NCBI news.\u202f\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559738&quot;:150,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<h5>We want to hear from you!<\/h5>\n<p><span data-contrast=\"auto\">If you have questions or would like to provide feedback, please reach out to us\u00a0at <a href=\"mailto:info@ncbi.nlm.nih.gov\">info@ncbi.nlm.nih.gov<\/a>.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Release 12.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP) is now available for download. You can search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. What&#8217;s new? The 12.0 release contains: 15,849 HMMs maintained by NCBI &hellip; <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">NCBI Hidden Markov Models (HMM) Release 12.0 Now Available!<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":11193,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"NCBI Hidden Markov Models (HMM) Release 12.0 Now Available!","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[693060756,693060700,693060701,15779425,693060702],"table_tags":[],"class_list":["post-11188","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-gene-ontology-go","tag-hidden-markov-models-hmm","tag-hmmer","tag-pgap","tag-protein-family-model"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NCBI Hidden Markov Models (HMM) Release 12.0 Now Available! - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NCBI Hidden Markov Models (HMM) Release 12.0 Now Available! - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"Release 12.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP) is now available for download. You can search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. What&#8217;s new? The 12.0 release contains: 15,849 HMMs maintained by NCBI &hellip; Continue reading NCBI Hidden Markov Models (HMM) Release 12.0 Now Available! &rarr;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/\" \/>\n<meta property=\"og:site_name\" content=\"NCBI Insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ncbi.nlm\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-24T13:57:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/04\/HMM_Release-4-e1681926363881.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1100\" \/>\n\t<meta property=\"og:image:height\" content=\"575\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"NCBI Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@NCBI\" \/>\n<meta name=\"twitter:site\" content=\"@NCBI\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"NCBI Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/\"},\"author\":{\"name\":\"NCBI Staff\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#\/schema\/person\/4f41ea6a31cea38a9a1b1419c048e50b\"},\"headline\":\"NCBI Hidden Markov Models (HMM) Release 12.0 Now Available!\",\"datePublished\":\"2023-04-24T13:57:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/\"},\"wordCount\":189,\"commentCount\":2,\"publisher\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#organization\"},\"image\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2023\/04\/HMM_Release-4-e1681926363881.png?fit=1100%2C575&ssl=1\",\"keywords\":[\"Gene Ontology (GO)\",\"Hidden Markov Models (HMM)\",\"HMMER\",\"NCBI Prokaryotic Genome Annotation Pipeline (PGAP)\",\"Protein Family Model\"],\"articleSection\":[\"What's New\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/\",\"url\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/04\/24\/hmm-release-12-0\/\",\"name\":\"NCBI Hidden Markov Models (HMM) Release 12.0 Now Available! 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