Add more subdomains
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proPSA
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<h1>proPSA</h1>
|
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<div class='row'>
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||||
<div class='col-lg-10'>
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||||
<dl class='row'>
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||||
<dt class='col-md-2'>Aliases</dt>
|
||||
<dd class='col-md-10'>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>[-2]proPSA</li>
|
||||
|
||||
<li class='list-inline-item'>free prostate-specific antigen (PSA) isoform</li>
|
||||
|
||||
<li class='list-inline-item'>proPSA</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt class='col-md-2'>Description</dt>
|
||||
<dd class='col-md-10'>
|
||||
ProPSA (-2), or [-2]proPSA, is a PSA isoform which has a leader peptide (-2) amino acids at its N terminal region and does not interact with ACT or alpha-2-macroglobulin or spermidine and therefore is detected as a separate isoform. ProPSA is produced primarily in the peripheral zone of the prostate gland and therefore is very useful in distinguishing between prostate cancer patients with PSA range of 2-10, from those who have BPH. Percent proPSA is the ratio of proPSA to free PSA.
|
||||
In July 2012 the FDA approved an assay measuring levels of [-2]proPSA for monitoring and diagnostic purposes.
|
||||
</dd>
|
||||
</dl>
|
||||
</div>
|
||||
<div class='col-lg-2'>
|
||||
<h5>Attributes</h5>
|
||||
<dl>
|
||||
<dt>QA State</dt>
|
||||
<dd>Curated</dd>
|
||||
<dt>Type</dt>
|
||||
<dd>Protein</dd>
|
||||
<dt>HGNC Name</dt>
|
||||
<dd></dd>
|
||||
</dl>
|
||||
</div>
|
||||
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|
||||
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||||
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||||
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||||
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|
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||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
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|
||||
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|
||||
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<a class='btn badge btn-secondary' href='http://www.fda.gov/regulatoryinformation/guidances/ucm125335.htm' title='Food & Drug Administration Certification'>
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||||
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|
||||
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||||
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|
||||
|
||||
|
||||
</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Prostate</dt>
|
||||
<dd>Curated</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/propsa/'>Logging in</a> may give you privileges to view additional information.
|
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|
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
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||||
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|
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</p>
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</div>
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</div>
|
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|
||||
|
||||
|
||||
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||||
</div>
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||||
</div>
|
||||
</div>
|
||||
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||||
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||||
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||||
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||||
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||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/propsa/'>Logging in</a> may give you privileges to view additional information.
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
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|
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</p>
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</div>
|
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|
||||
|
||||
|
||||
|
||||
</div>
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<div class='tab-pane fade' id='pubs-section' role='tabpanel' aria-labelledby='pubs-tab'>
|
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||||
<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/publications/21419439-1803-a-multicenter-study-of-2pro-prostate-specific-antigen-combined-with-prostate-specific-antigen-and-free-prostate-specific-antigen-for-prostate-cancer-detection-in-the-20-to-100-ngml-prostate-specific-antigen-range/'>A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng/ml prostate specific antigen range.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/20447916-2633-a-prospective-multicenter-national-cancer-institute-early-detection-research-network-study-of-2propsa-improving-prostate-cancer-detection-and-correlating-with-cancer-aggressiveness/'>A prospective, multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/22759214-97-from-prostate-specific-antigen-psa-to-precursor-psa-propsa-isoforms-a-review-of-the-emerging-role-of-propsas-in-the-detection-and-management-of-early-prostate-cancer/'>From prostate-specific antigen (PSA) to precursor PSA (proPSA) isoforms: a review of the emerging role of proPSAs in the detection and management of early prostate cancer.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/22542565-98-multi-center-analytical-performance-evaluation-of-the-access-hybritech-p2psa-immunoassay/'>Multi-center analytical performance evaluation of the Access Hybritech® p2PSA immunoassay.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/18550118-1360-2proenzyme-prostate-specific-antigen-for-prostate-cancer-detection-a-national-cancer-institute-early-detection-research-network-validation-study/'>[-2]proenzyme prostate specific antigen for prostate cancer detection: a national cancer institute early detection research network validation study.</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
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<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/510k-substantial-equivalence-determination-decision-summary/'>510(k) SUBSTANTIAL EQUIVALENCE DETERMINATION DECISION SUMMARY</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/draft-directional-insert/'>Draft Directional Insert</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/fda-medical-device-description-of-hybritech-p2psa-assay/'>FDA Medical Device description of Hybritech p2PSA assay</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/genecards-record-for-human-kallikrein-3-also-known-as-psa/'>Genecards record for human kallikrein 3, also known as PSA</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/ncbi-gene-entry-for-human-klk3/'>NCBI Gene entry for human KLK3</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/nci-fact-sheet-for-prostate-specific-antigen-psa-test/'>NCI Fact Sheet for Prostate-Specific Antigen (PSA) Test</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/national-cancer-institute-news-note/'>National Cancer Institute News Note</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/summary-of-safety-and-effectiveness-data-ssed/'>Summary of Safety and Effectiveness Data (SSED)</a></li>
|
||||
|
||||
</ul>
|
||||
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|
||||
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|
||||
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||||
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||||
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<div class='row'>
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<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/propsa/'>Logging in</a> may give you privileges to view additional information.
|
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|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
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||||
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|
||||
</p>
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|
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|
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|
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|
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|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-10'>
|
||||
<dl class='row'>
|
||||
<dt class='col-md-2'>Aliases</dt>
|
||||
<dd class='col-md-10'>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>DCP</li>
|
||||
|
||||
<li class='list-inline-item'>Des-gamma carboxyprothrombin</li>
|
||||
|
||||
<li class='list-inline-item'>PIVKA II</li>
|
||||
|
||||
<li class='list-inline-item'>PIVKA-II</li>
|
||||
|
||||
<li class='list-inline-item'>Prothrombin Induced by Vitamin K Absence II</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt class='col-md-2'>Description</dt>
|
||||
<dd class='col-md-10'>
|
||||
Des-gamma-carboxy prothrombin (DCP) is a non-functional precursor of prothrombin. Prothrombin, produced by the liver, serves a critical role in normal hemostasis. Functional prothrombin contains several gamma-carboxy-glutamic acid (Gla) residues that are produced as the result of post-translational modification of glutamic acid residues mediated by vitamin K dependent gamma-glutamyl carboxylase. The formation of Gla residues can be impaired in patients with vitamin K deficiency or in patients receiving oral anticoagulant therapy. DCP lacks thrombotic activity and has been shown in multiple studies to be present in the serum of patients with HCC. DCP arises from an acquired defect in the post-translational carboxylation of the pro-thrombin precursor in malignant hepatocytes.
|
||||
</dd>
|
||||
</dl>
|
||||
</div>
|
||||
<div class='col-lg-2'>
|
||||
<h5>Attributes</h5>
|
||||
<dl>
|
||||
<dt>QA State</dt>
|
||||
<dd>Curated</dd>
|
||||
<dt>Type</dt>
|
||||
<dd>Protein</dd>
|
||||
<dt>HGNC Name</dt>
|
||||
<dd></dd>
|
||||
</dl>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
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|
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|
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|
||||
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|
||||
aria-selected='true'
|
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>
|
||||
Liver
|
||||
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|
||||
|
||||
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|
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<div class='tab-content ml-3' id='organs-sections'>
|
||||
|
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||||
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|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>
|
||||
<h5 class='mt-1 mb-0 pb-0'>
|
||||
<a class='btn badge btn-secondary' href='http://www.fda.gov/regulatoryinformation/guidances/ucm125335.htm' title='Food & Drug Administration Certification'>
|
||||
<i class='bi bi-patch-check'></i> FDA
|
||||
</a>
|
||||
</h5>
|
||||
|
||||
|
||||
</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Liver</dt>
|
||||
<dd>Curated</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/dcp/'>Logging in</a> may give you privileges to view additional information.
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|
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
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||||
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|
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||||
|
||||
|
||||
|
||||
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|
||||
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||||
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|
||||
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|
||||
|
||||
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||||
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|
||||
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||||
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||||
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||||
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||||
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||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/dcp/'>Logging in</a> may give you privileges to view additional information.
|
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|
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
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||||
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|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
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|
||||
|
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|
||||
<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/publications/19362088-1863-alpha-fetoprotein-des-gamma-carboxyprothrombin-and-lectin-bound-alpha-fetoprotein-in-early-hepatocellular-carcinoma/'>Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/12717392-23-des-gamma-carboxyprothrombin-can-differentiate-hepatocellular-carcinoma-from-nonmalignant-chronic-liver-disease-in-american-patients/'>Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/6201741-325-des-gamma-carboxy-abnormal-prothrombin-as-a-serum-marker-of-primary-hepatocellular-carcinoma/'>Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/17522429-33-risk-factors-for-hepatocellular-carcinoma-may-impair-the-performance-of-biomarkers-a-comparison-of-afp-dcp-and-afp-l3/'>Risk factors for hepatocellular carcinoma may impair the performance of biomarkers: a comparison of AFP, DCP, and AFP-L3.</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
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||||
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|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/fda-product-classification/'>FDA product classification</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/jorge-a-marrero-md-ms/'>Jorge A. Marrero, M.D., M.S.</a></li>
|
||||
|
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</ul>
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|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/dcp/'>Logging in</a> may give you privileges to view additional information.
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||||
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
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||||
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||||
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APOA1
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<div class='row'>
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|
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<dl class='row'>
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<dt class='col-md-2'>Aliases</dt>
|
||||
<dd class='col-md-10'>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>APOA1</li>
|
||||
|
||||
<li class='list-inline-item'>Apo-AI</li>
|
||||
|
||||
<li class='list-inline-item'>ApoA-I</li>
|
||||
|
||||
<li class='list-inline-item'>Apolipoprotein A-I</li>
|
||||
|
||||
<li class='list-inline-item'>Apolipoprotein A1</li>
|
||||
|
||||
<li class='list-inline-item'>Apolipoproteins (Apo) A1</li>
|
||||
|
||||
<li class='list-inline-item'>MGC117399</li>
|
||||
|
||||
<li class='list-inline-item'>apolipoprotein A-I</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt class='col-md-2'>Description</dt>
|
||||
<dd class='col-md-10'>
|
||||
APOA1, a secreted protein belonging to the apolipoprotein A1/A4/E family, participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, APOA1 activates spermatozoa motility. This protein is a major protein of plasma HDL and is also found in chylomicrons. It is synthesized in the liver and small intestine. Defects in APOA1 are a cause of several diseases: 1) high density lipoprotein deficiency type 2 (HDLD2), also known as familial hypoalphalipoproteinemia, for which inheritance is autosomal dominant; 2) the low HDL levels observed in high density lipoprotein deficiency type 1 (HDLD1), also known as analphalipoproteinemia or Tangier disease (TGD), a recessive disorder characterized by the absence of plasma HDL, accumulation of cholesteryl esters, premature coronary artery disease, hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness; 3) amyloid polyneuropathy-nephropathy Iowa type (AMYLIOWA), also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III, a hereditary generalized amyloidosis due to deposition of amyloid mainly constituted by apolipoprotein A1; 4) amyloidosis type 8 (AMYL8), also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis, a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids.
|
||||
</dd>
|
||||
</dl>
|
||||
</div>
|
||||
<div class='col-lg-2'>
|
||||
<h5>Attributes</h5>
|
||||
<dl>
|
||||
<dt>QA State</dt>
|
||||
<dd>Curated</dd>
|
||||
<dt>Type</dt>
|
||||
<dd>Proteomic</dd>
|
||||
<dt>HGNC Name</dt>
|
||||
<dd>APOA1</dd>
|
||||
</dl>
|
||||
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||||
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|
||||
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||||
|
||||
|
||||
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aria-selected='true'
|
||||
>
|
||||
Breast
|
||||
</button>
|
||||
|
||||
<button class='nav-link '
|
||||
id='organ-lung-tab' data-bs-toggle='pill' type='button' role='tab'
|
||||
data-bs-target='#organ-lung-section'
|
||||
aria-selected='false'
|
||||
>
|
||||
Lung
|
||||
</button>
|
||||
|
||||
<button class='nav-link '
|
||||
id='organ-ovary-tab' data-bs-toggle='pill' type='button' role='tab'
|
||||
data-bs-target='#organ-ovary-section'
|
||||
aria-selected='false'
|
||||
>
|
||||
Ovary
|
||||
</button>
|
||||
|
||||
<button class='nav-link '
|
||||
id='organ-pancreas-tab' data-bs-toggle='pill' type='button' role='tab'
|
||||
data-bs-target='#organ-pancreas-section'
|
||||
aria-selected='false'
|
||||
>
|
||||
Pancreas
|
||||
</button>
|
||||
|
||||
</div>
|
||||
<div class='tab-content ml-3' id='organs-sections'>
|
||||
|
||||
<div class='tab-pane fade show active' role='tabpanel'
|
||||
id='organ-breast-section' aria-labelledby='organ-breast-tab'>
|
||||
|
||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item small'>None</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Breast</dt>
|
||||
<dd>Under Review</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/apoa1/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
|
||||
<div class='tab-pane fade ' role='tabpanel'
|
||||
id='organ-lung-section' aria-labelledby='organ-lung-tab'>
|
||||
|
||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item small'>None</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Lung</dt>
|
||||
<dd></dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/apoa1/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
|
||||
<div class='tab-pane fade ' role='tabpanel'
|
||||
id='organ-ovary-section' aria-labelledby='organ-ovary-tab'>
|
||||
|
||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item small'>None</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Ovary</dt>
|
||||
<dd>Curated</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/apoa1/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
|
||||
<div class='tab-pane fade ' role='tabpanel'
|
||||
id='organ-pancreas-section' aria-labelledby='organ-pancreas-tab'>
|
||||
|
||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item small'>None</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Pancreas</dt>
|
||||
<dd>Under Review</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/apoa1/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
|
||||
</div>
|
||||
</div>
|
||||
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='studies-section' role='tabpanel' aria-labelledby='studies-tab'>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/apoa1/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='pubs-section' role='tabpanel' aria-labelledby='pubs-tab'>
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/publications/21372037-1781-a-framework-for-evaluating-biomarkers-for-early-detection-validation-of-biomarker-panels-for-ovarian-cancer/'>A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/21685906-279-a-targeted-proteomics-based-pipeline-for-verification-of-biomarkers-in-plasma/'>A targeted proteomics-based pipeline for verification of biomarkers in plasma.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/21372036-3035-ovarian-cancer-biomarker-performance-in-prostate-lung-colorectal-and-ovarian-cancer-screening-trial-specimens/'>Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens.</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='resources-section' role='tabpanel' aria-labelledby='resources-tab'>
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/entrez-protein-reference-sequence-for-apolipoprotein-a-i-preproprotein-homo-sapiens/'>Entrez Protein Reference Sequence for apolipoprotein A-I preproprotein [Homo sapiens]</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/hgnc-entry-for-human-apolipoprotein-a-i-apoa1/'>HGNC entry for human apolipoprotein A-I APOA1</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/kegg-entry-for-human-apolipoprotein-a-i-apoa1/'>KEGG entry for human apolipoprotein A-I APOA1</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/uniprotkbswiss-prot-entry-for-p02647-apoa1_human/'>UniProtKB/Swiss-Prot entry for P02647 (APOA1_HUMAN)</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='datacollections-section' role='tabpanel'
|
||||
aria-labelledby='datacollections-tab'>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/apoa1/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
</div>
|
||||
|
||||
</div>
|
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<title>
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FSH
|
||||
|
||||
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||||
|
||||
— Early Detection Research Network
|
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|
||||
|
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|
||||
</title><meta name='description' content='FSH is a biomarker being researched by EDRN'/><meta name="twitter:card" content="summary"><meta name="twitter:title" content="FSH"><meta name="twitter:description" content="FSH is a biomarker being researched by EDRN"><meta property="og:url" content="https://edrn.nci.nih.gov/data-and-resources/biomarkers/fshb/"><meta property="og:title" content="FSH"><meta property="og:description" content="FSH is a biomarker being researched by EDRN"><meta property="og:site_name" content="Early Detection Research Network"><meta itemprop="url" content="https://edrn.nci.nih.gov/data-and-resources/biomarkers/fshb/"><meta itemprop="name" content="FSH"><meta itemprop="description" content="FSH is a biomarker being researched by EDRN"><title>FSH</title><meta name="description" content="FSH is a biomarker being researched by EDRN">
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|
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|
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|
||||
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|
||||
<dt class='col-md-2'>Aliases</dt>
|
||||
<dd class='col-md-10'>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>FSH</li>
|
||||
|
||||
<li class='list-inline-item'>FSH-B</li>
|
||||
|
||||
<li class='list-inline-item'>FSH-beta</li>
|
||||
|
||||
<li class='list-inline-item'>FSHB</li>
|
||||
|
||||
<li class='list-inline-item'>Follitropin beta chain</li>
|
||||
|
||||
<li class='list-inline-item'>Follitropin subunit beta</li>
|
||||
|
||||
<li class='list-inline-item'>follicle stimulating hormone, beta polypeptide</li>
|
||||
|
||||
<li class='list-inline-item'>follicle-stimulating hormone beta subunit</li>
|
||||
|
||||
<li class='list-inline-item'>follitropin, beta chain</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt class='col-md-2'>Description</dt>
|
||||
<dd class='col-md-10'>
|
||||
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
|
||||
Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. FSHB belongs to the glycoprotein hormones subunit beta family. There are two transcript variants from alternative splicing that each encode the same protein.
|
||||
</dd>
|
||||
</dl>
|
||||
</div>
|
||||
<div class='col-lg-2'>
|
||||
<h5>Attributes</h5>
|
||||
<dl>
|
||||
<dt>QA State</dt>
|
||||
<dd>Curated</dd>
|
||||
<dt>Type</dt>
|
||||
<dd>Protein</dd>
|
||||
<dt>HGNC Name</dt>
|
||||
<dd>FSHB</dd>
|
||||
</dl>
|
||||
</div>
|
||||
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|
||||
|
||||
|
||||
|
||||
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||||
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||||
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|
||||
Ovary
|
||||
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|
||||
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||||
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|
||||
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|
||||
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||||
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|
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||||
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||||
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|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item small'>None</li>
|
||||
|
||||
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|
||||
</dd>
|
||||
<dt>QA State for Ovary</dt>
|
||||
<dd>Curated</dd>
|
||||
</dl>
|
||||
|
||||
|
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|
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|
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|
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|
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|
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|
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|
||||
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|
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|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
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<li><a href='/data-and-resources/publications/21372037-1781-a-framework-for-evaluating-biomarkers-for-early-detection-validation-of-biomarker-panels-for-ovarian-cancer/'>A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer.</a></li>
|
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|
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|
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|
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<li><a href='/data-and-resources/miscellaneous-resources/kegg-entry-for-human-follicle-stimulating-hormone-beta-polypeptide-fshb/'>KEGG entry for human follicle stimulating hormone, beta polypeptide FSHB</a></li>
|
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|
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|
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|
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<li><a href='/data-and-resources/miscellaneous-resources/uniprotkbswiss-prot-entry-for-p01225-fshb_human/'>UniProtKB/Swiss-Prot entry for P01225 (FSHB_HUMAN)</a></li>
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AFP-L3
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— Early Detection Research Network
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<li class='breadcrumb-item active'>AFP-L3</li>
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||||
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||||
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|
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<div class='row'>
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<div class='col-md-12 pt-3'>
|
||||
<h1>AFP-L3</h1>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
<div class='row py-3'>
|
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<button class='nav-link' id='organs-tab' data-bs-toggle='pill'
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</li>
|
||||
</ul>
|
||||
|
||||
<div class='tab-content p-3' id='biomarker-sections'>
|
||||
<div class='tab-pane fade show active' id='basics-section' role='tabpanel'
|
||||
aria-labelledby='basics-tab'>
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-10'>
|
||||
<dl class='row'>
|
||||
<dt class='col-md-2'>Aliases</dt>
|
||||
<dd class='col-md-10'>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>AFP-L3</li>
|
||||
|
||||
<li class='list-inline-item'>Lectin-bound alpha-fetoprotein</li>
|
||||
|
||||
<li class='list-inline-item'>lectin-bound AFP</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt class='col-md-2'>Description</dt>
|
||||
<dd class='col-md-10'>
|
||||
AFP-L3, also known as lectin-bound AFP, is an isoform of AFP, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. The L3 isoform is specific to malignant tumors and its detected presence may serve to identify patients who could benefit from monitoring for the development of HCC in high risk populations (i.e. chronic hepatitis, liver cirrhosis).
|
||||
</dd>
|
||||
</dl>
|
||||
</div>
|
||||
<div class='col-lg-2'>
|
||||
<h5>Attributes</h5>
|
||||
<dl>
|
||||
<dt>QA State</dt>
|
||||
<dd>Curated</dd>
|
||||
<dt>Type</dt>
|
||||
<dd>Protein</dd>
|
||||
<dt>HGNC Name</dt>
|
||||
<dd>AFP-L3</dd>
|
||||
</dl>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='organs-section' role='tabpanel' aria-labelledby='organs-tab'>
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
|
||||
<div class='d-flex align-items-start'>
|
||||
<div class='nav flex-column nav-pills me-4 pe-3' id='organs-tabs' role='tablist'
|
||||
aria-oreintation='vertical'>
|
||||
|
||||
<button class='nav-link active'
|
||||
id='organ-liver-tab' data-bs-toggle='pill' type='button' role='tab'
|
||||
data-bs-target='#organ-liver-section'
|
||||
aria-selected='true'
|
||||
>
|
||||
Liver
|
||||
</button>
|
||||
|
||||
</div>
|
||||
<div class='tab-content ml-3' id='organs-sections'>
|
||||
|
||||
<div class='tab-pane fade show active' role='tabpanel'
|
||||
id='organ-liver-section' aria-labelledby='organ-liver-tab'>
|
||||
|
||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>
|
||||
<h5 class='mt-1 mb-0 pb-0'>
|
||||
<a class='btn badge btn-secondary' href='http://www.fda.gov/regulatoryinformation/guidances/ucm125335.htm' title='Food & Drug Administration Certification'>
|
||||
<i class='bi bi-patch-check'></i> FDA
|
||||
</a>
|
||||
</h5>
|
||||
|
||||
|
||||
</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Liver</dt>
|
||||
<dd>Curated</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/afp-l3/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
|
||||
</div>
|
||||
</div>
|
||||
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='studies-section' role='tabpanel' aria-labelledby='studies-tab'>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/afp-l3/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='pubs-section' role='tabpanel' aria-labelledby='pubs-tab'>
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/publications/11694234-36-afp-l3-a-new-generation-of-tumor-marker-for-hepatocellular-carcinoma/'>AFP-L3: a new generation of tumor marker for hepatocellular carcinoma.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/19362088-1863-alpha-fetoprotein-des-gamma-carboxyprothrombin-and-lectin-bound-alpha-fetoprotein-in-early-hepatocellular-carcinoma/'>Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/18422961-38-des-gamma-carboxyprothrombin-alpha-fetoprotein-and-afp-l3-in-patients-with-chronic-hepatitis-cirrhosis-and-hepatocellular-carcinoma/'>Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/17522429-33-risk-factors-for-hepatocellular-carcinoma-may-impair-the-performance-of-biomarkers-a-comparison-of-afp-dcp-and-afp-l3/'>Risk factors for hepatocellular carcinoma may impair the performance of biomarkers: a comparison of AFP, DCP, and AFP-L3.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/16534867-37-serum-tumor-markers-for-detection-of-hepatocellular-carcinoma/'>Serum tumor markers for detection of hepatocellular carcinoma.</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='resources-section' role='tabpanel' aria-labelledby='resources-tab'>
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/fda-web-page-describing-approval-of-afp-l3/'>FDA web page describing approval of AFP-L3</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/genecards-entry-for-human-afp-of-which-afp-l3-is-an-isoform/'>GeneCards entry for human AFP, of which AFP-L3 is an isoform</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/hgnc-entry-317-for-afp-human-alpha-fetoprotein-of-which-afp-l3-is-an-isoform/'>HGNC entry 317 for AFP, human alpha-fetoprotein, of which AFP-L3 is an isoform</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/protein-refseq-sequence-for-alpha-fetoprotein-precursor-homo-sapiens/'>Protein RefSeq sequence for alpha-fetoprotein precursor [Homo sapiens]</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/uniprotkbswiss-prot-entry-p02771-human-alpha-fetoprotein/'>UniProtKB/Swiss-Prot entry P02771 human Alpha-fetoprotein</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='datacollections-section' role='tabpanel'
|
||||
aria-labelledby='datacollections-tab'>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/afp-l3/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
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<dt class='col-md-2'>Aliases</dt>
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||||
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||||
<li class='list-inline-item'>OVA1</li>
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||||
<dt class='col-md-2'>Description</dt>
|
||||
<dd class='col-md-10'>
|
||||
The OVA1 diagnostic test is comprised of five biomarkers: CA125, transthyretin (prealbumin), apolipprotein A1 (Apo A-1), beta-2 microglobulin, and transferrin. OVA1 is an In Vitro Diagnostic Multivariate Index Assay (IVDMIA) of Proteomic Biomarkers test that analyzes the serum levels of these five proteomic biomarkers. OVA1 is the first FDA approved test for assessing ovarian cancer risk in women previously diagnosed with an ovarian mass, and already scheduled for surgery. The OVA1 algorithm combines the results of these levels with information on the menopause status of the patient to classify the patient into a low- or high-risk group. The results of the OVA1 test can help determine patients needing referral to a gynecologic oncologist for their surgery.
|
||||
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|
||||
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||||
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|
||||
<div class='col-lg-2'>
|
||||
<h5>Attributes</h5>
|
||||
<dl>
|
||||
<dt>QA State</dt>
|
||||
<dd>Curated</dd>
|
||||
<dt>Type</dt>
|
||||
<dd>Protein</dd>
|
||||
<dt>HGNC Name</dt>
|
||||
<dd></dd>
|
||||
</dl>
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Ovary
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||||
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<dt>QA State for Ovary</dt>
|
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<div class='row'>
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<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
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<a href='/_util/portal-login?next=/data-and-resources/biomarkers/ova1/'>Logging in</a> may give you privileges to view additional information.
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
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</p>
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<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/ova1/'>Logging in</a> may give you privileges to view additional information.
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
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|
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<li><a href='/data-and-resources/publications/20110452-144-a-recipe-for-proteomics-diagnostic-test-development-the-ova1-test-from-biomarker-discovery-to-fda-clearance/'>A recipe for proteomics diagnostic test development: the OVA1 test, from biomarker discovery to FDA clearance.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/22543921-1991-differential-diagnosis-of-a-pelvic-mass-improved-algorithms-and-novel-biomarkers/'>Differential diagnosis of a pelvic mass: improved algorithms and novel biomarkers.</a></li>
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<li><a href='/data-and-resources/publications/20962299-1805-the-road-from-discovery-to-clinical-diagnostics-lessons-learned-from-the-first-fda-cleared-in-vitro-diagnostic-multivariate-index-assay-of-proteomic-biomarkers/'>The road from discovery to clinical diagnostics: lessons learned from the first FDA-cleared in vitro diagnostic multivariate index assay of proteomic biomarkers.</a></li>
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||||
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|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
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<a href='/_util/portal-login?next=/data-and-resources/biomarkers/ova1/'>Logging in</a> may give you privileges to view additional information.
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PCA3
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— Early Detection Research Network
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<h1>PCA3</h1>
|
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|
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|
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|
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|
||||
|
||||
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|
||||
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|
||||
aria-labelledby='basics-tab'>
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-10'>
|
||||
<dl class='row'>
|
||||
<dt class='col-md-2'>Aliases</dt>
|
||||
<dd class='col-md-10'>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>DD3</li>
|
||||
|
||||
<li class='list-inline-item'>NCRNA00019</li>
|
||||
|
||||
<li class='list-inline-item'>PCA3</li>
|
||||
|
||||
<li class='list-inline-item'>PCAT3</li>
|
||||
|
||||
<li class='list-inline-item'>non-protein coding RNA 19</li>
|
||||
|
||||
<li class='list-inline-item'>prostate cancer antigen 3</li>
|
||||
|
||||
<li class='list-inline-item'>prostate cancer antigen 3 (non-protein coding)</li>
|
||||
|
||||
<li class='list-inline-item'>prostate cancer associated transcript 3 (non-protein coding)</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt class='col-md-2'>Description</dt>
|
||||
<dd class='col-md-10'>
|
||||
The prostate cancer antigen 3 (PCA3) gene is a highly specific biomarker upregulated in prostate cancer. Because there is no extensive open reading frame, the gene is thought to express a noncoding RNA.
|
||||
The FDA has approved an assay for prostate cancer that uses the ratio of PCA3 RNA to PSA RNA in urine. The assay is used to help physicians determine the need for repeat prostate biopsies in men 50 years of age or older who have had a previous negative biopsy. When used in conjunction with other clinical information, the use of this test can reduce the need for unnecessary prostate biopsies.
|
||||
</dd>
|
||||
</dl>
|
||||
</div>
|
||||
<div class='col-lg-2'>
|
||||
<h5>Attributes</h5>
|
||||
<dl>
|
||||
<dt>QA State</dt>
|
||||
<dd>Curated</dd>
|
||||
<dt>Type</dt>
|
||||
<dd>Gene</dd>
|
||||
<dt>HGNC Name</dt>
|
||||
<dd>PCA3</dd>
|
||||
</dl>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='organs-section' role='tabpanel' aria-labelledby='organs-tab'>
|
||||
|
||||
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|
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|
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|
||||
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|
||||
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|
||||
aria-oreintation='vertical'>
|
||||
|
||||
<button class='nav-link active'
|
||||
id='organ-prostate-tab' data-bs-toggle='pill' type='button' role='tab'
|
||||
data-bs-target='#organ-prostate-section'
|
||||
aria-selected='true'
|
||||
>
|
||||
Prostate
|
||||
</button>
|
||||
|
||||
</div>
|
||||
<div class='tab-content ml-3' id='organs-sections'>
|
||||
|
||||
<div class='tab-pane fade show active' role='tabpanel'
|
||||
id='organ-prostate-section' aria-labelledby='organ-prostate-tab'>
|
||||
|
||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>
|
||||
<h5 class='mt-1 mb-0 pb-0'>
|
||||
<a class='btn badge btn-secondary' href='http://www.fda.gov/regulatoryinformation/guidances/ucm125335.htm' title='Food & Drug Administration Certification'>
|
||||
<i class='bi bi-patch-check'></i> FDA
|
||||
</a>
|
||||
</h5>
|
||||
|
||||
|
||||
</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Prostate</dt>
|
||||
<dd>Curated</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/pca3/'>Logging in</a> may give you privileges to view additional information.
|
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|
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
|
||||
</div>
|
||||
</div>
|
||||
|
||||
</div>
|
||||
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|
||||
|
||||
|
||||
|
||||
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|
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|
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<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/pca3/'>Logging in</a> may give you privileges to view additional information.
|
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|
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
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|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
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|
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<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/publications/18245462-1390-a-first-generation-multiplex-biomarker-analysis-of-urine-for-the-early-detection-of-prostate-cancer/'>A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/25385735-2632-can-urinary-pca3-supplement-psa-in-the-early-detection-of-prostate-cancer/'>Can urinary PCA3 supplement PSA in the early detection of prostate cancer?</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/21600800-2146-combining-urinary-detection-of-tmprss2erg-and-pca3-with-serum-psa-to-predict-diagnosis-of-prostate-cancer/'>Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/23086769-2120-correlation-of-urine-tmprss2erg-and-pca3-to-erg-and-total-prostate-cancer-burden/'>Correlation of urine TMPRSS2:ERG and PCA3 to ERG+ and total prostate cancer burden.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/22245323-130-molecular-diagnosis-of-prostate-cancer-pca3-and-tmprss2erg-gene-fusion/'>Molecular diagnosis of prostate cancer: PCA3 and TMPRSS2:ERG gene fusion.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/21820580-95-prostate-cancer-gene-3-score-predicts-prostate-biopsy-outcome-in-men-receiving-dutasteride-for-prevention-of-prostate-cancer-results-from-the-reduce-trial/'>Prostate cancer gene 3 score predicts prostate biopsy outcome in men receiving dutasteride for prevention of prostate cancer: results from the REDUCE trial.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/19517474-142-rational-approach-to-implementation-of-prostate-cancer-antigen-3-into-clinical-care/'>Rational approach to implementation of prostate cancer antigen 3 into clinical care.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/23515404-2090-urinary-tmprss2erg-and-pca3-in-an-active-surveillance-cohort-results-from-a-baseline-analysis-in-the-canary-prostate-active-surveillance-study/'>Urinary TMPRSS2:ERG and PCA3 in an active surveillance cohort: results from a baseline analysis in the Canary Prostate Active Surveillance Study.</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
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|
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|
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||||
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|
||||
<div class='col-lg-12'>
|
||||
<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/fda-website-for-pca3-assay/'>FDA website for PCA3 assay</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/genecards-entry-for-human-pca3/'>GeneCards entry for human PCA3</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/hgnc-entry-for-human-prostate-cancer-antigen-3-pca3/'>HGNC entry for human prostate cancer antigen 3 PCA3</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/ncbi-gene-entry-for-human-pca3/'>NCBI Gene entry for human PCA3</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/omim-entry-for-prostate-cancer-antigen-3-pca3/'>OMIM entry for PROSTATE CANCER ANTIGEN 3; PCA3</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
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<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/pca3/'>Logging in</a> may give you privileges to view additional information.
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
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TF
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— Early Detection Research Network
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</ul>
|
||||
|
||||
<div class='tab-content p-3' id='biomarker-sections'>
|
||||
<div class='tab-pane fade show active' id='basics-section' role='tabpanel'
|
||||
aria-labelledby='basics-tab'>
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-10'>
|
||||
<dl class='row'>
|
||||
<dt class='col-md-2'>Aliases</dt>
|
||||
<dd class='col-md-10'>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>Beta-1 Metal-Binding Globulin</li>
|
||||
|
||||
<li class='list-inline-item'>Epididymis Secretory Sperm Binding Protein Li 71p</li>
|
||||
|
||||
<li class='list-inline-item'>HEL-S-71p</li>
|
||||
|
||||
<li class='list-inline-item'>PRO1557</li>
|
||||
|
||||
<li class='list-inline-item'>PRO2086</li>
|
||||
|
||||
<li class='list-inline-item'>Serotransferrin</li>
|
||||
|
||||
<li class='list-inline-item'>Siderophilin</li>
|
||||
|
||||
<li class='list-inline-item'>TF</li>
|
||||
|
||||
<li class='list-inline-item'>TFQTL1</li>
|
||||
|
||||
<li class='list-inline-item'>Transferrin</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt class='col-md-2'>Description</dt>
|
||||
<dd class='col-md-10'>
|
||||
TF, or transferrin, a glycoprotein with an approximate molecular weight of 76.5 kDa, is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum.
|
||||
</dd>
|
||||
</dl>
|
||||
</div>
|
||||
<div class='col-lg-2'>
|
||||
<h5>Attributes</h5>
|
||||
<dl>
|
||||
<dt>QA State</dt>
|
||||
<dd>Curated</dd>
|
||||
<dt>Type</dt>
|
||||
<dd>Protein</dd>
|
||||
<dt>HGNC Name</dt>
|
||||
<dd>TF</dd>
|
||||
</dl>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='organs-section' role='tabpanel' aria-labelledby='organs-tab'>
|
||||
|
||||
<div class='row'>
|
||||
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|
||||
|
||||
<div class='d-flex align-items-start'>
|
||||
<div class='nav flex-column nav-pills me-4 pe-3' id='organs-tabs' role='tablist'
|
||||
aria-oreintation='vertical'>
|
||||
|
||||
<button class='nav-link active'
|
||||
id='organ-breast-tab' data-bs-toggle='pill' type='button' role='tab'
|
||||
data-bs-target='#organ-breast-section'
|
||||
aria-selected='true'
|
||||
>
|
||||
Breast
|
||||
</button>
|
||||
|
||||
<button class='nav-link '
|
||||
id='organ-ovary-tab' data-bs-toggle='pill' type='button' role='tab'
|
||||
data-bs-target='#organ-ovary-section'
|
||||
aria-selected='false'
|
||||
>
|
||||
Ovary
|
||||
</button>
|
||||
|
||||
<button class='nav-link '
|
||||
id='organ-prostate-tab' data-bs-toggle='pill' type='button' role='tab'
|
||||
data-bs-target='#organ-prostate-section'
|
||||
aria-selected='false'
|
||||
>
|
||||
Prostate
|
||||
</button>
|
||||
|
||||
</div>
|
||||
<div class='tab-content ml-3' id='organs-sections'>
|
||||
|
||||
<div class='tab-pane fade show active' role='tabpanel'
|
||||
id='organ-breast-section' aria-labelledby='organ-breast-tab'>
|
||||
|
||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item small'>None</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Breast</dt>
|
||||
<dd>Under Review</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/tf/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
|
||||
<div class='tab-pane fade ' role='tabpanel'
|
||||
id='organ-ovary-section' aria-labelledby='organ-ovary-tab'>
|
||||
|
||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item small'>None</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Ovary</dt>
|
||||
<dd>Curated</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
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|
||||
</p>
|
||||
</div>
|
||||
</div>
|
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|
||||
|
||||
|
||||
|
||||
</div>
|
||||
|
||||
<div class='tab-pane fade ' role='tabpanel'
|
||||
id='organ-prostate-section' aria-labelledby='organ-prostate-tab'>
|
||||
|
||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item small'>None</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Prostate</dt>
|
||||
<dd>Under Review</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
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<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/tf/'>Logging in</a> may give you privileges to view additional information.
|
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Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
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|
||||
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|
||||
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|
||||
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|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
|
||||
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|
||||
</div>
|
||||
|
||||
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|
||||
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|
||||
|
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|
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|
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|
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|
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|
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<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/tf/'>Logging in</a> may give you privileges to view additional information.
|
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|
||||
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|
||||
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|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
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|
||||
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|
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|
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|
||||
<div class='col-lg-12'>
|
||||
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|
||||
|
||||
<li><a href='/data-and-resources/publications/21372037-1781-a-framework-for-evaluating-biomarkers-for-early-detection-validation-of-biomarker-panels-for-ovarian-cancer/'>A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/21685906-279-a-targeted-proteomics-based-pipeline-for-verification-of-biomarkers-in-plasma/'>A targeted proteomics-based pipeline for verification of biomarkers in plasma.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/23028830-2046-an-accurate-prostate-cancer-prognosticator-using-a-seven-gene-signature-plus-gleason-score-and-taking-cell-type-heterogeneity-into-account/'>An accurate prostate cancer prognosticator using a seven-gene signature plus Gleason score and taking cell type heterogeneity into account.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/21459804-1883-diagnosis-of-prostate-cancer-using-differentially-expressed-genes-in-stroma/'>Diagnosis of prostate cancer using differentially expressed genes in stroma.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/22870216-159-expression-changes-in-the-stroma-of-prostate-cancer-predict-subsequent-relapse/'>Expression changes in the stroma of prostate cancer predict subsequent relapse.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/21372036-3035-ovarian-cancer-biomarker-performance-in-prostate-lung-colorectal-and-ovarian-cancer-screening-trial-specimens/'>Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens.</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
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|
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|
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|
||||
|
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|
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|
||||
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|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/entrez-protein-reference-sequence-for-serotransferrin-precursor-homo-sapiens/'>Entrez Protein Reference Sequence for serotransferrin precursor [Homo sapiens]</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/genecards-entry-for-human-tf/'>GeneCards entry for human TF</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/hgnc-entry-for-human-transferrin-tf/'>HGNC entry for human transferrin TF</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/kegg-entry-for-human-transferrin-tf/'>KEGG entry for human transferrin TF</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/omim-entry-for-human-tf/'>OMIM entry for human TF</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/uniprotkbswiss-prot-entry-for-p02787-trfe_human/'>UniProtKB/Swiss-Prot entry for P02787 (TRFE_HUMAN)</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
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|
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|
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<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/tf/'>Logging in</a> may give you privileges to view additional information.
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|
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|
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||||
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ROMA
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— Early Detection Research Network
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Biomarkers
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<li class='breadcrumb-item active'>ROMA</li>
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|
||||
|
||||
|
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|
||||
|
||||
<div class='row'>
|
||||
<div class='col-md-12 pt-3'>
|
||||
<h1>ROMA</h1>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
<div class='row py-3'>
|
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<button class='nav-link active' id='basics-tab' data-bs-toggle='pill'
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aria-selected='true'>Basics</button>
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</li>
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||||
<li class='nav-item' role='presentation'>
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||||
<button class='nav-link' id='organs-tab' data-bs-toggle='pill'
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||||
data-bs-target='#organs-section' type='button' role='tab' aria-controls='organs-section'
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||||
aria-selected='false'>Organs</button>
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||||
</li>
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||||
<li class='nav-item' role='presentation'>
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||||
<button class='nav-link' id='studies-tab' data-bs-toggle='pill'
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<button class='nav-link' id='pubs-tab' data-bs-toggle='pill'
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</li>
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<li class='nav-item' role='presentation'>
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<button class='nav-link' id='resources-tab' data-bs-toggle='pill'
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aria-selected='false'>Resources</button>
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</li>
|
||||
<li class='nav-item' role='presentation'>
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||||
<button class='nav-link' id='datacollections-tab' data-bs-toggle='pill'
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data-bs-target='#datacollections-section' type='button' role='tab'
|
||||
aria-controls='datacollections-section' aria-selected='false'>Data Collections</button>
|
||||
</li>
|
||||
</ul>
|
||||
|
||||
<div class='tab-content p-3' id='biomarker-sections'>
|
||||
<div class='tab-pane fade show active' id='basics-section' role='tabpanel'
|
||||
aria-labelledby='basics-tab'>
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-10'>
|
||||
<dl class='row'>
|
||||
<dt class='col-md-2'>Aliases</dt>
|
||||
<dd class='col-md-10'>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>ROMA</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt class='col-md-2'>Description</dt>
|
||||
<dd class='col-md-10'>
|
||||
The Risk of Ovarian Malignancy Algorithm (ROMA) algorithm was approved by the FDA in 2011. Research demonstrates that examining levels of HE4 and CA125 using the ROMA algorithm shows the highest accuracy in determining ovarian cancer risk in pre- and post-menopausal women who have an ovarian mass present.
|
||||
</dd>
|
||||
</dl>
|
||||
</div>
|
||||
<div class='col-lg-2'>
|
||||
<h5>Attributes</h5>
|
||||
<dl>
|
||||
<dt>QA State</dt>
|
||||
<dd>Curated</dd>
|
||||
<dt>Type</dt>
|
||||
<dd>Protein</dd>
|
||||
<dt>HGNC Name</dt>
|
||||
<dd></dd>
|
||||
</dl>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='organs-section' role='tabpanel' aria-labelledby='organs-tab'>
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
|
||||
<div class='d-flex align-items-start'>
|
||||
<div class='nav flex-column nav-pills me-4 pe-3' id='organs-tabs' role='tablist'
|
||||
aria-oreintation='vertical'>
|
||||
|
||||
<button class='nav-link active'
|
||||
id='organ-ovary-tab' data-bs-toggle='pill' type='button' role='tab'
|
||||
data-bs-target='#organ-ovary-section'
|
||||
aria-selected='true'
|
||||
>
|
||||
Ovary
|
||||
</button>
|
||||
|
||||
</div>
|
||||
<div class='tab-content ml-3' id='organs-sections'>
|
||||
|
||||
<div class='tab-pane fade show active' role='tabpanel'
|
||||
id='organ-ovary-section' aria-labelledby='organ-ovary-tab'>
|
||||
|
||||
<dl>
|
||||
<dt>Certifications</dt>
|
||||
<dd>
|
||||
<ul class='list-inline'>
|
||||
|
||||
<li class='list-inline-item'>
|
||||
<h5 class='mt-1 mb-0 pb-0'>
|
||||
<a class='btn badge btn-secondary' href='http://www.fda.gov/regulatoryinformation/guidances/ucm125335.htm' title='Food & Drug Administration Certification'>
|
||||
<i class='bi bi-patch-check'></i> FDA
|
||||
</a>
|
||||
</h5>
|
||||
|
||||
|
||||
</li>
|
||||
|
||||
</ul>
|
||||
</dd>
|
||||
<dt>QA State for Ovary</dt>
|
||||
<dd>Under Review</dd>
|
||||
</dl>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/roma/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
|
||||
</div>
|
||||
</div>
|
||||
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='studies-section' role='tabpanel' aria-labelledby='studies-tab'>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/roma/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='pubs-section' role='tabpanel' aria-labelledby='pubs-tab'>
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/publications/20471625-1757-comparison-of-a-novel-multiple-marker-assay-vs-the-risk-of-malignancy-index-for-the-prediction-of-epithelial-ovarian-cancer-in-patients-with-a-pelvic-mass/'>Comparison of a novel multiple marker assay vs the Risk of Malignancy Index for the prediction of epithelial ovarian cancer in patients with a pelvic mass.</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/publications/22543921-1991-differential-diagnosis-of-a-pelvic-mass-improved-algorithms-and-novel-biomarkers/'>Differential diagnosis of a pelvic mass: improved algorithms and novel biomarkers.</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='resources-section' role='tabpanel' aria-labelledby='resources-tab'>
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='col-lg-12'>
|
||||
<ul class='list-unstyled'>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/fda-approval-of-roma/'>FDA approval of ROMA</a></li>
|
||||
|
||||
<li><a href='/data-and-resources/miscellaneous-resources/press-release-women-infants-brown-university/'>Press release, Women & Infants, Brown University</a></li>
|
||||
|
||||
</ul>
|
||||
</div>
|
||||
</div>
|
||||
|
||||
|
||||
|
||||
</div>
|
||||
<div class='tab-pane fade' id='datacollections-section' role='tabpanel'
|
||||
aria-labelledby='datacollections-tab'>
|
||||
|
||||
|
||||
|
||||
<div class='row'>
|
||||
<div class='alert alert-warning'>
|
||||
<h4 class='alert-heading'><i class='bi bi-incognito'></i> Non-Public Biomarker</h4>
|
||||
<p>
|
||||
|
||||
Organ-specific information for this biomarker is currently being annotated or is "under review".
|
||||
<a href='/_util/portal-login?next=/data-and-resources/biomarkers/roma/'>Logging in</a> may give you privileges to view additional information.
|
||||
|
||||
Contact the <a href="mailto:ic-portal@jpl.nasa.gov">Informatics Center</a> if you believe you
|
||||
should have access.
|
||||
</p>
|
||||
</div>
|
||||
</div>
|
||||
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Your EDRN username and password give you access to several resources. Where would you like to log into today?
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<dt>Who should do this?</dt>
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<i class="pe-2 fs-1 bi bi-unlock"></i> I want to log into the DMCC's private website, also known as the "secure" website
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|
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The Data Management and Coordinating Center provides a "secure website"
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where you can get a lot of the same information here on the EDRN portal.
|
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But you can also update information and find some other unique tools.
|
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|
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|
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|
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|
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|
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|
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<dt>Why is it the "secure website"?</dt>
|
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<dd>That's just what it's been called for a long time. There isn't an "insecure website". There's
|
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a public website (this one) and a private website—the DMCC's "secure website", which you can log into by clicking the button below.</dd>
|
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|
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|
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|
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href='https://www.compass.fhcrc.org/enterEDRN/?param=plin&p=3&why=4&extra=71.3'>
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<i class='bi bi-box-arrow-up-right'></i> Take me there!
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<button class='accordion-button' type='button' data-bs-toggle='collapse'
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aria-controls='login-labcas-target'>
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<i class="pe-2 fs-1 bi bi-activity"></i> I want to log into the Cancer
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Biomarker Data Commons (LabCAS)
|
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|
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The EDRN Cancer Biomarker Data Commons has both
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public and access-controlled scientific data. Logging in with your
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<dl>
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<dt>Who should do this?</dt>
|
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<dd>Anyone who needs access to private scientific data warehoused in the Data Commons.
|
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</dd>
|
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<dt>What is "LabCAS"?</dt>
|
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<dd>LabCAS is the Laboratory Catalog and Archive Service, the software that runs the EDRN Cancer Biomarker Data Commons.</dd>
|
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|
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|
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<h2 data-block-key="13215">Important Links</h2><p data-block-key="an9b0">The following links may be informative and/or provide utility for changing or recovering your password:</p><ul><li data-block-key="9cnxb"><a href="https://www.compass.fhcrc.org/edrns/pub/user/resetPwd.aspx?t=pwd&sub=form&w=1&p=3&extra=7">Forgot your password?</a></li><li data-block-key="w41tm">Need to <a href="https://www.compass.fhcrc.org/edrns/pub/user/changePwd.aspx?t=pwd&sub=form&w=1&p=3">change your password</a>?</li><li data-block-key="7sppi">EDRN members: <a href="https://www.compass.fhcrc.org/edrns/pub/user/application.aspx?t=app&sub=form1&w=1&p=3&q=4&r=5&s=6&extra1=1">request new login?</a></li><li data-block-key="ra1ei">See also the <a href="#us-government-warning">US Government Warning</a> (below)</li></ul><h3 data-block-key="q5435">US Government Warning</h3><p data-block-key="h42m5">This warning banner provides privacy and security notices consistent with applicable federal laws, directives, and other federal guidance for accessing this Government system, which includes ⑴ this computer network, ⑵ all computers connected to this network, and ⑶ all devices and storage media attached to this network or to a computer on this network.</p><p data-block-key="kprc0">This system is provided for Government-authorized use only. Unauthorized or improper use of this system is prohibited and may result in disciplinary action and/or civil and criminal penalties. Personal use of social media and networking sites on this system is limited as to not interfere with official work duties and is subject to monitoring.</p>
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647
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gtag('js', new Date());
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gtag('config', 'G-CLTPCSVTDK');
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class='img-fluid'
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alt='Logo of the Early Detection Research Network, part of the National Cancer Institute'
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Protocols
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Publications
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<h1>Log In</h1>
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One EDRN account. Many possible destinations.
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Your EDRN username and password give you access to several resources. Where would you like to log into today?
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<i class="pe-2 fs-1 bi bi-door-open"></i> I want to log in here, to the EDRN public portal
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Logging in here—to the EDRN public portal—may afford you access to
|
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|
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on this site. Use your EDRN username and password in the below form
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to log in.
|
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|
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<dl>
|
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<dt>Who should do this?</dt>
|
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<dd>People who want access to additional, private information here.</dd>
|
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<dt>What about website editors?</dt>
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|
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|
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<label for="id_username">Username:</label>
|
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|
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|
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|
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|
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<p>
|
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<label for="id_password">Password:</label>
|
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|
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|
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|
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|
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<i class="pe-2 fs-1 bi bi-unlock"></i> I want to log into the DMCC's private website, also known as the "secure" website
|
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|
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|
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aria-labelledby='login-dmcc-header' data-bs-parent='#login-accordion'>
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|
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<p>
|
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The Data Management and Coordinating Center provides a "secure website"
|
||||
where you can get a lot of the same information here on the EDRN portal.
|
||||
But you can also update information and find some other unique tools.
|
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Additionally, you can change your EDRN password (whether you've forgotten
|
||||
it or not) there—or request a new account.
|
||||
</p>
|
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<dl>
|
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<dt>Who should do this?</dt>
|
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<dd>EDRN members only who need to view <em>and update</em> information on protocols, membership, publications, and so forth.</dd>
|
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<dt>Why is it the "secure website"?</dt>
|
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<dd>That's just what it's been called for a long time. There isn't an "insecure website". There's
|
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a public website (this one) and a private website—the DMCC's "secure website", which you can log into by clicking the button below.</dd>
|
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|
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|
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|
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<i class='bi bi-box-arrow-up-right'></i> Take me there!
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|
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|
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aria-controls='login-labcas-target'>
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<i class="pe-2 fs-1 bi bi-activity"></i> I want to log into the Cancer
|
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Biomarker Data Commons (LabCAS)
|
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|
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|
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|
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aria-labelledby='login-labcas-header' data-bs-parent='#login-accordion'>
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|
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<p>
|
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The EDRN Cancer Biomarker Data Commons has both
|
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|
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EDRN username and password may give you access to additional data.
|
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|
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<dl>
|
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<dt>Who should do this?</dt>
|
||||
<dd>Anyone who needs access to private scientific data warehoused in the Data Commons.
|
||||
</dd>
|
||||
<dt>What is "LabCAS"?</dt>
|
||||
<dd>LabCAS is the Laboratory Catalog and Archive Service, the software that runs the EDRN Cancer Biomarker Data Commons.</dd>
|
||||
</dl>
|
||||
<p>
|
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|
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|
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<i class='bi bi-box-arrow-up-right'></i> Take me there!
|
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|
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|
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|
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|
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|
||||
|
||||
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|
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|
||||
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|
||||
|
||||
<h2 data-block-key="13215">Important Links</h2><p data-block-key="an9b0">The following links may be informative and/or provide utility for changing or recovering your password:</p><ul><li data-block-key="9cnxb"><a href="https://www.compass.fhcrc.org/edrns/pub/user/resetPwd.aspx?t=pwd&sub=form&w=1&p=3&extra=7">Forgot your password?</a></li><li data-block-key="w41tm">Need to <a href="https://www.compass.fhcrc.org/edrns/pub/user/changePwd.aspx?t=pwd&sub=form&w=1&p=3">change your password</a>?</li><li data-block-key="7sppi">EDRN members: <a href="https://www.compass.fhcrc.org/edrns/pub/user/application.aspx?t=app&sub=form1&w=1&p=3&q=4&r=5&s=6&extra1=1">request new login?</a></li><li data-block-key="ra1ei">See also the <a href="#us-government-warning">US Government Warning</a> (below)</li></ul><h3 data-block-key="q5435">US Government Warning</h3><p data-block-key="h42m5">This warning banner provides privacy and security notices consistent with applicable federal laws, directives, and other federal guidance for accessing this Government system, which includes ⑴ this computer network, ⑵ all computers connected to this network, and ⑶ all devices and storage media attached to this network or to a computer on this network.</p><p data-block-key="kprc0">This system is provided for Government-authorized use only. Unauthorized or improper use of this system is prohibited and may result in disciplinary action and/or civil and criminal penalties. Personal use of social media and networking sites on this system is limited as to not interfere with official work duties and is subject to monitoring.</p>
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